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拓撲異構(gòu)酶相關(guān)功能蛋白4-2抗體

英文名稱 TRF4-2
中文名稱 拓撲異構(gòu)酶相關(guān)功能蛋白4-2抗體
別    名 PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3.
  
說 明 書 0.2ml  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRF4-2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion

Function:
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.

Subunit:
Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase

Subcellular Location:
Nuclearxy-9819R    C2orf692號染色體開放閱讀框69抗體
xy-9825R    C3orf183號染色體開放閱讀框18抗體
xy-1046R    CCL4巨噬細胞炎癥因子1β /MIP-1β抗體
xy-0684R    CD147細胞外基質(zhì)金屬蛋白酶誘導(dǎo)因子抗體
xy-1014R    CD11b整合素αM/巨噬細胞表面分子抗體
xy-0468R    CD31血小板內(nèi)皮細胞黏附分子-1抗體
xy-0195R    CD31血小板內(nèi)皮細胞黏附分子1抗體
xy-0646R    CD34CD34抗體
xy-1100R    CD36CD36抗體
xy-7087R    CARD6凋亡加強結(jié)構(gòu)域蛋白6抗體
xy-7090R    CARD17凋亡加強結(jié)構(gòu)域蛋白17抗體
xy-7085R    CARD4凋亡加強結(jié)構(gòu)域蛋白4抗體
xy-15192R    C4orf34 4號染色體開放閱讀框34抗體
xy-9080R    CKI gamma 3酪蛋白激酶1γ3/CKI γ3抗體
xy-7089R    CARD9凋亡加強結(jié)構(gòu)域蛋白9抗體
xy-13920R    Cholesterol Oxidase膽固醇氧化酶抗體
xy-6859R    Caspase 14半胱胺酸蛋白酶蛋白14抗體
xy-6860R    Caspase 5半胱胺酸蛋白酶蛋白5抗體
xy-10045R    CSFV豬瘟病毒抗體
xy-10045M    CSFV豬瘟病毒抗體
xy-12120R    Chromogranin C/Sg II嗜鉻粒蛋白C抗體
xy-12111R    CHRNA10煙堿型乙酰膽堿受體α10/AChRα10抗體
xy-12112R    CHRNA6煙堿型乙酰膽堿受體α6/AChRα6抗體
xy-12113R    CHRNA9煙堿型乙酰膽堿受體α9/AChRα9抗體
xy-12114R    CHRND煙堿型乙酰膽堿受體δ/AChRδ抗體
xy-7088R    CARD8凋亡加強結(jié)構(gòu)域蛋白8抗體
xy-6854R    CARD7凋亡加強結(jié)構(gòu)域蛋白7抗體
xy-6857R    beta COPβ衣被蛋白抗體
xy-6858R    Caspase 4+Caspase 11半胱胺酸蛋白酶4/11抗體