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TRFP蛋白抗體

英文名稱 TRFP
中文名稱 TRFP蛋白抗體
別    名 MED20; Mediator complex subunit 20; MED20_HUMAN; TRF proximal protein homolog; TRFP.
 
說 明 書 0.2ml  
研究領域 細胞生物  轉錄調節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRFP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]

Function:
TRFP / MED20 is a member of the mediator complex that can act as both a positive and negative regulator of transcription. The mediator complex interacts with RNA pol II and its associated proteins, the general transcription factors. Mediator proteins serve as a bridge connecting the activator and basal transcription machinery.

Subunit:
Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.xy-2489R    CD9CD9蛋白抗體
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xy-2491R    CD27CD27抗體
xy-2495R    CD30CD30抗體
xy-2496R    CD43CD43抗體
xy-2497R    CD48CD48抗體
xy-2507R    CD44 CD44抗體
xy-2508R    CD11c整合素αX抗體
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xy-2474R    CD93CD93抗體
xy-2476R    CCL6嗜酸粒細胞趨化蛋白CCL6抗體
xy-15254R    C6orf816號染色體開放閱讀框81抗體
xy-2475R    CCL4巨噬細胞炎性蛋白1β抗體
xy-2643R    CD158NK細胞抑制性受體2DL4抗體
xy-2644R    CD158iNK細胞抑制性受體2DS4抗體
xy-2645R    CD158eNK細胞抑制性受體3DL1抗體
xy-15271R    C7orf467號染色體開放閱讀框46抗體
xy-5948R    CIP2A蛋白磷酸酶PP2A癌抑制蛋白抗體
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