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TSN蛋白抗體

英文名稱 Translin
中文名稱 TSN蛋白抗體
別    名 BCLF 1; BCLF1; Component 3 of promoter of RISC; RCHF1; recombination hotspot associated factor; recombination hotspot binding protein; rehf 1; REHF1; TBRBP; Translin; TRSLN; TSN; TSN_HUMAN.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Translin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.

Subunit:
Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

Subcellular Location:
Cytoplasm. Nucleusxy-11546R    DUSP6雙特異性蛋白磷酸酶6/絲裂原活化蛋白激酶磷酸酶3抗體
xy-11547R    Dab1磷脂蛋白受體Dab1抗體
xy-11548R    Phospho-Dab1 (Tyr198) 磷酸化磷脂蛋白受體Dab1抗體
xy-11550R    DLX2同源轉(zhuǎn)錄因子DLX2抗體
xy-2983R    Desmocollin 2橋粒糖蛋白2/橋粒糖蛋白3抗體
xy-6307R    Desmocollin 1橋粒糖蛋白1抗體
xy-6630R    Destrin 19肌動蛋白解聚因子19抗體
xy-6929R    DCTN1動力蛋白激活蛋白1抗體
xy-6725R    Desmoglein 1橋粒芯糖蛋白1
xy-5801R    DLC1胞漿動力蛋白輕鏈1抗體
xy-11827R    DRGX背根神經(jīng)節(jié)同源蛋白DRGX抗體
xy-5909R    DeltaDDeltaD抗體
xy-5938R    DAT1神經(jīng)細(xì)胞特異性轉(zhuǎn)錄因子DAT1抗體
xy-6234R    DOK3對接蛋白3抗體
xy-5931R    DCUN1D2DCN1樣蛋白2抗體
xy-4949R    DNAJB6熱休克蛋白J2抗體
xy-6259R    Dyrk1B雙特異性酪氨酸磷酸化調(diào)節(jié)激酶1B抗體
xy-12999R    DGKE二?；视图っ?抗體
xy-2102R    DNA PKcsDNA依賴蛋白激酶催化亞基抗體
xy-12369R    DUX4雙同源框蛋白4抗體
xy-12285R    DAZ1無精癥缺失基因1抗體
xy-5257R    Phospho-CHK2 (ser516)磷酸化細(xì)胞周期檢測點(diǎn)激酶2抗體
xy-4150R    Kv2.1鉀通道蛋白DRK1抗體
xy-6001R    DRG1GTP發(fā)育調(diào)控結(jié)合蛋白1抗體
xy-6003R    DAL1細(xì)胞骨架4.1蛋白家族DAL1抗體
xy-3785R    DRAK2DAP凋亡誘導(dǎo)蛋白激酶2抗體
xy-5999R    DAB2信號轉(zhuǎn)導(dǎo)功能磷蛋白DAB2抗體
xy-6000R    DACH1細(xì)胞命運(yùn)決定因子DACH1抗體
xy-5998R    DAB2IPDab2相互作用蛋白抗體
xy-5056R    DECR1線粒體2,4-雙烯酰輔酶A還原酶1抗體
xy-7746R    DCTN3動力蛋白激活蛋白亞基3抗體
xy-7747R    DCTN6動力蛋白激活蛋白6抗體
xy-3673R    DIO2脫碘酶2抗體