B淋巴細(xì)胞基因1抗體 返回列表頁(yè)

B淋巴細(xì)胞基因1抗體

英文名稱 TLE4
中文名稱 B淋巴細(xì)胞基因1抗體
別    名 B lymphocyte gene 1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho 4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless (Drosophila) homolog; TLE4; transducin-like enhancer of split 4; transducin-like enhancer of split 4; TLE4_HUMAN.
  
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLE4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases. xy-4279R    Growth Arrest Specific Protein 7生長(zhǎng)休止特定蛋白7抗體
xy-8454R    phospho-GluR1 (Ser836)磷酸化谷氨酸受體1抗體
xy-12025R    GPR116G蛋白偶聯(lián)受體116抗體
xy-4109R    G protein alpha 12鳥苷酸調(diào)節(jié)蛋白12抗體
xy-5355R    phospho-GFAP (Ser8)磷酸化膠質(zhì)纖維酸性蛋白抗體
xy-5356R    phospho-GABBR2 (Ser783)磷酸化G氨基丁酸B型受體2抗體
xy-5357R    phospho-GABBR2 (Ser892) 磷酸化G氨基丁酸B型受體2抗體
xy-5720R    GDF10生長(zhǎng)分化因子10抗體（TGF-β超家族10）
xy-15369R    GPCR LOC51210G蛋白偶聯(lián)受體LOC51210蛋白抗體
xy-5715R    GIG34細(xì)胞生長(zhǎng)抑制蛋白34
xy-6579R    Growth Hormone生長(zhǎng)激素抗體
xy-13460R    GMPPAGDP甘露糖焦磷酸化酶抗體
xy-6564R    GPR171G蛋白偶聯(lián)受體171抗體
xy-11847R    GPM6B神經(jīng)細(xì)胞膜糖蛋白M6b
xy-6247R    GUK1鳥苷酸激酶GMK抗體
xy-4691R    Galactocerebroside半乳糖腦苷脂酶抗體
xy-7540R    GRK5G蛋白偶聯(lián)受體激酶5抗體
xy-7502R    GTP binding protein REM1GTP結(jié)合蛋白R(shí)EM1抗體
xy-4692R    phospho-GSK3 Alpha(Ser21)磷酸化糖原合酶激酶-3α抗體
xy-11461R    GDF7生長(zhǎng)分化因子7抗體
xy-7057R    Glucokinase regulatory protein葡萄糖激酶調(diào)節(jié)蛋白抗體
xy-8402R    GCLCγ谷氨酰半胱氨酸合成酶抗體（γ-GCSc）
xy-8403R    GCOM1GCOM1蛋白抗體
xy-8405R    GFOD2葡萄糖果糖還原酶2抗體
xy-8406R    GFRAL膠質(zhì)細(xì)胞系源性神經(jīng)營(yíng)養(yǎng)因子受體α1樣蛋白抗體
xy-8407R    GHDCGHDC蛋白抗體
xy-8408R    GK5甘油激酶5抗體
xy-8409R    GLB1L3β半乳糖苷酶1樣蛋白3抗體
xy-8410R    GLCCI1糖皮質(zhì)激素誘導(dǎo)轉(zhuǎn)錄蛋白1抗體
xy-8411R    GLIPR2腦膠質(zhì)瘤發(fā)病相關(guān)蛋白2抗體
xy-11725R    GDAP1神經(jīng)節(jié)苷脂誘導(dǎo)分化相關(guān)蛋白1抗體