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TATA結合蛋白TBP抗體

英文名稱 TBP
中文名稱 TATA結合蛋白TBP抗體
別    名 GTF2D; GTF2D1; MGC117320; MGC126054; MGC126055; SCA 17; SCA17; TATA binding factor; TATA box binding protein; TATA box factor; TATA sequence binding protein; TATA sequence-binding protein; TATA binding protein TBP; TATA-binding factor; TATA-box factor; TATA-box-binding protein; TBP; TBP_HUMAN; TF2D; TFIID; Transcription initiation factor TFIID TBP subunit.
 
說 明 書 0.2ml  
研究領域 細胞生物  神經生物學  干細胞  轉錄調節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TATA binding protein TBP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

Function:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.xy-4126R    GPI糖磷脂酰肌醇抗體
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xy-3177R    phospho-GAB2 (Ser159)磷酸化接頭蛋白Gab2抗體
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xy-4062R    Glycerol kinase甘油激酶抗體
xy-4061R    GPD2線粒體甘油三磷酸脫氫酶2抗體
xy-4143R    Glutamine synthetase谷氨酰胺合成酶/谷氨酸氨連接酶抗體
xy-2388R    GPD1甘油三磷酸脫氫酶1抗體
xy-2367R    ganglioside GM1神經節(jié)苷酯抗體
xy-5163R    GSTA3谷胱甘肽S轉移酶A3抗體
xy-5177R    phospho-GADD153 (Ser30)磷酸化GADD153抗體
xy-3939R    G protein alpha SG蛋白αS抗體（鳥嘌呤核苷酸結合蛋白Gα s）
xy-3940R    G protein beta 4G蛋白β4抗體/鳥嘌呤核苷酸結合蛋白β亞基4
xy-3942R    G protein beta 2G蛋白β2抗體/鳥嘌呤核苷酸結合蛋白β亞基2
xy-3944R    GNG2G蛋白γ2抗體/鳥嘌呤核苷酸結合蛋白γ2抗體
xy-4079R    phospho-GSK3 Beta (Tyr216)磷酸化糖原合酶激酶3β抗體
xy-15366R    GPR92G蛋白偶聯受體GPR92蛋白抗體
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xy-13243R    G gamma14G蛋白偶聯受體γ14抗體
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xy-6325R    GLUT10葡萄糖轉運蛋白10抗體
xy-4585R    GRPP腸高血糖素相關肽抗體