甲狀腺激素受體相互作用蛋白4抗體 返回列表頁

甲狀腺激素受體相互作用蛋白4抗體

英文名稱 TRIP4
中文名稱 甲狀腺激素受體相互作用蛋白4抗體
別    名 Activating signal cointegrator 1; ASC1; ASC 1; ASC-1; HsT17391; Thyroid hormone receptor interactor 4; Thyroid receptor interacting protein 4; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP 4; TRIP-4; TRIP4; TRIP4_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRIP4/ASC (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm. However, when serum starved in the presence of ligand of coexpressed CBP or SRC-1, ASC-1 remains in the nucleus. This behavior of ASC-1 suggests that it may play an important role in establishing distinct co-activator complexes under different cellular conditions.

Function:
Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.

Subunit:
Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and HELIC1. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and dihydrotestosterone-dependent manner (By similarity). Interacts with NEK6. 

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic under conditions of serum deprivation. Co-localizes with NEK6 in the centrosome. 

Post-translational modifications:
Phosphorylated by NEK6. xy-0808R    HCMV UL49人巨細(xì)胞病毒UL49蛋白抗體
xy-1279R    HLA E人類白細(xì)胞抗原E抗體
xy-15448R    HECTD3E3連接酶抑制素受體3抗體
xy-6447R    HSP1精子魚精蛋白P1抗體
xy-1025R    HGF肝細(xì)胞生長因子抗體
xy-1813R    HDAC2組蛋白去乙酰化酶2抗體
xy-0343R    large S protein人乙肝病毒Large S蛋白抗體
xy-1085R    ErbB 4HER4抗體
xy-0402R    BRI3BP宮頸癌原基因1/bri3結(jié)合蛋白抗體
xy-0221R    HCV Core protein丙肝病毒核心抗原C區(qū)抗體
xy-0218R    HCV-NS1丙型肝炎病毒-NS1抗體
xy-0219R    HCV-NS3丙型肝炎病毒-NS3抗體
xy-0213R    HCV-NS4a丙型肝炎病毒-NS4a抗體
xy-0344R    H5N1 Matrix Protein 2A型禽流感病毒H5N1-M2蛋白抗體
xy-1235R    Hyaluronidase-1透明質(zhì)酸酶/玻璃酸酶抗體
xy-0540R    HAI-1肝細(xì)胞生長因子激活物抑制劑抗體
xym-0966M    HA tag(12CA5)HA tag標(biāo)簽單克隆抗體
xy-0408R    Heamachrome血紅素抗體
xy-0212R    Hepatitis E Virus ORF3 戊型肝炎病毒抗體
xy-1814R    HRG1神經(jīng)調(diào)節(jié)蛋白1抗體
xy-1817R    HRG Beta1神經(jīng)膠質(zhì)生長因子/神經(jīng)調(diào)節(jié)蛋白β抗體
xy-1818R    HINT1組氨酸三聚體核苷結(jié)合蛋白1抗體
xy-1819R    HDAC3組蛋白去乙?；?抗體
xy-15435R    HDX高度發(fā)散同源異型盒蛋白抗體
xy-12354R    Adenovirus hexon protein腺病毒六鄰體蛋白抗體
xy-6339R    HDLBP高密度脂蛋白結(jié)合蛋白抗體
xy-8634R    HNF3-alpha轉(zhuǎn)錄因子HNF-3α抗體
xy-9430R    HSPB7熱休克蛋白β7抗體
xy-15447R    HECTD2E3連接酶抑制素受體2抗體
xy-15411R    HAPLN3透明質(zhì)酸及粘蛋白3抗體