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Toll樣受體8抗體

英文名稱 TLR8
中文名稱 Toll樣受體8抗體
別    名 CD 288; CD288; CD288 antigen; MGC119599; MGC119600; TLR 8; TLR-8; Tlr8; TLR8_HUMAN; Toll Like Receptor 8; Toll-like receptor 8.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  細胞周期蛋白  細胞膜受體  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Horse, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLR 8
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFkB signaling pathway, suggesting that they play a role in the immune response.

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.xy-4947R    IL-1 Alpha白介素1α/IL-1α抗體
xy-11300R    phospho-IL2 Receptor beta (Tyr364)磷酸化白介素2受體β鏈抗體
xy-11301R    INSL3胰島素樣蛋白3抗體
xy-8680R    IRE1a內(nèi)質(zhì)網(wǎng)核信號轉(zhuǎn)導蛋白a1抗體
xy-4986R    rhIL-18重組人白細胞介素18抗體
xy-9914R    ITIH4α胰蛋白酶重鏈H4抗體
xy-0298R    IGBP1免疫球蛋白結(jié)合蛋白-1抗體
xy-9904R    IGFALS胰島素樣生長因子酸不穩(wěn)定亞基ALS抗體
xym-0862M    Insulin(1D4:)豬胰島素單克隆抗體
xy-2907R    IKK alphaKB抑制蛋白激酶α/IκBα/IKK-α/IKKα/I-κB-α 抗體
xy-0855R    Insulin抗重組人胰島素抗體
xy-3399R    Phospho-INPPL1(Tyr1135)磷酸化肌醇聚磷酸鹽磷酸酶樣蛋白1抗體
xy-0681R    Insulin Receptor胰島素受體抗體
xy-0260R    Insulin Receptor Alpha胰島素受體α抗體
xy-0290R    Insulin Receptor Beta胰島素受體β抗體
xy-7557R    IKK alpha + IKK betaKB抑制蛋白激酶α/β抗體
xy-0767R    IL-12白介素12抗體
xy-9704R    IFI35干擾素誘導35蛋白抗體
xy-9705R    ITM2A完整膜蛋白E25A抗體
xy-0825R    IFABP小腸型脂肪酸結(jié)合蛋白抗體
xy-0018M    IDE胰島素降解酶抗體
xy-2910R    IKK betaKB抑制蛋白激酶β抗體
xy-2608R    IL-17RD白介素17受體D抗體
xy-2609R    IL-17B白介素-17B抗體
xy-0902M    IAA吲哚乙酸/植物生長素單克隆抗體
xy-2458R    IL-4R白細胞介素4受體抗體IL-4Rα
xy-2545R    IL-2R gamma白介素2受體γ鏈抗體
xy-2594R    IL-1R1白介素1受體1抗體
xy-2595R    IL-1R2白介素1受體2抗體
xy-2619R    IL-20R alpha白介素20受體α鏈抗體
xy-2620R    IL-20RB白介素20受體β鏈抗體
xy-0902R    IAA吲哚乙酸抗體/植物生長素抗體
xy-2641R    Integrin alpha 6整合素α6抗體