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端粒酶調(diào)節(jié)相關(guān)蛋白抗體

英文名稱 Tartrate Resistant Acid Phosphatase
中文名稱 端粒酶調(diào)節(jié)相關(guān)蛋白抗體
別    名 Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TrATPase; Type 5 acid phosphatase.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRAP/Tartrate Resistant Acid Phosphatase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation.

Function:
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Subunit:
Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Subcellular Location:
Lysosome.xy-8997R    Annexin VI膜粘連蛋白6抗體
xy-9401R    ANKRD42錨蛋白重復(fù)結(jié)構(gòu)域蛋白42抗體
xy-7738R    Anillin胞環(huán)蛋白肌動(dòng)蛋白結(jié)合蛋白抗體
xy-7697R    Adenovirus 5 E1A binding protein腺病毒5結(jié)合蛋白BS69抗體(骨形態(tài)發(fā)生蛋白受體相關(guān)分子1)
xy-2314R    APOA1載脂蛋白A1抗體
xy-4007R    ATG16L自噬相關(guān)蛋白16A抗體
xy-5201R    phospho-ATG4D(Ser15)磷酸化自噬相關(guān)蛋白4D抗體
xy-5196R    Phospho-ATG4C(Ser451)磷酸化自噬相關(guān)蛋白4C抗體
xy-5197R    phospho-ATG7(Ser95)磷酸化自噬相關(guān)蛋白7抗體
xy-5198R    phospho-ATG16A(Ser287)磷酸化自噬相關(guān)蛋白16A抗體
xy-5199R    phospho-ATG9A(Ser735)磷酸化自噬相關(guān)蛋白9A抗體
xy-5202R    phospho-ATG4D(Ser341)磷酸化自噬相關(guān)蛋白4D抗體
xy-5203R    phospho-ATG4D(Ser467)磷酸化自噬相關(guān)蛋白4D抗體
xy-5210R    phospho-TEM8 (Tyr382)磷酸化腫瘤血管內(nèi)皮標(biāo)志物8抗體
xy-5207R    phospho-ATG4A(Ser100)磷酸化自噬相關(guān)蛋白4A抗體
xy-5208R    phospho-ATG4C(Ser166)磷酸化自噬相關(guān)蛋白4C抗體
xy-5206R    phospho-ATG16A(Ser213)磷酸化自噬相關(guān)蛋白16A抗體
xy-5209R    phospho-AKT3 (Ser472)磷酸化蛋白激酶AKT3抗體
xy-5211R    phospho-ADRB2 (Ser261)磷酸化腎上腺素能受體β2抗體
xy-5214R    phospho-AQP2(Ser261)磷酸化水通道蛋白2抗體
xy-5204R    phospho-ATG3 (Tyr18)磷酸化自噬相關(guān)蛋白3抗體
xy-4026R    ALDOB醛縮酶2抗體
xy-3975R    AMY2A胰腺α淀粉酶抗體
xy-7961R    ANKRD11錨蛋白重復(fù)結(jié)構(gòu)域蛋白11抗體
xy-8440R    phospho-c-ABL1+2 (Tyr393+429)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-8449R    phospho-ATF2 (Thr53)磷酸化活化復(fù)制因子2抗體
xy-5026R    AKR1D1醛固酮還原酶家族1成員D1抗體
xy-5027R    ARP4肝血管生成素相關(guān)蛋白抗體
xy-5028R    ABHD5自水解酶結(jié)構(gòu)域5蛋白抗體
xy-5031R    ACOT8?；o酶A硫酯酶8
xy-5032R    Agpat2溶血磷脂酸?；D(zhuǎn)移酶β抗體
xy-10084R    AFP4bAFP4b蛋白抗體
xy-5036R    APOC2載脂蛋白C2抗體
xy-5035R    Apolipoprotein A V載脂蛋白A5抗體
xy-5034R    APOA2載脂蛋白A2抗體
xy-5033R    AGPAT4溶血磷脂酸酰基轉(zhuǎn)移酶D抗體
xy-5039R    APOE3載脂蛋白E3抗體
xy-5985R    ABI3ABI基因家族2抗體
xy-5983R    AARE氧化蛋白質(zhì)水解酶
xy-2390R    Aconitase 2鐵調(diào)節(jié)蛋白2抗體
xy-5106R    ALDH1乙醛脫氫酶1型抗體
xy-10082R    AFP4aAFP4a蛋白抗體
xy-9296R    ARHGAP32Rho GTP酶激活蛋白32抗體
xy-9886R    Adropin能量平衡相關(guān)蛋白抗體
xy-4696R    AEV polyprotein禽腦脊髓炎病毒AEV抗體