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T淋巴細(xì)胞膜蛋白4抗體

英文名稱 TIM4
中文名稱 T淋巴細(xì)胞膜蛋白4抗體
別    名 SMUCKLER; Spleen, mucin-containing, knockout of lymphotoxin protein; T cell immunoglobulin and mucin domain containing protein 4; T-cell immunoglobulin and mucin domain containing 4; T-cell membrane protein 4; TIM-4; Tim4; Tim 4; TIMD 4.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 免疫學(xué)  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIM4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. Studies have shown that TIM 4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM 1, and that this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM 4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM 4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM 1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Similarity:
Belongs to the immunoglobulin superfamily. TIM family. 
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
91937xy-2490R    CD23CD23/FcεRII抗體
xy-2491R    CD27CD27抗體
xy-2495R    CD30CD30抗體
xy-2496R    CD43CD43抗體
xy-2497R    CD48CD48抗體
xy-2507R    CD44 CD44抗體
xy-2508R    CD11c整合素αX抗體
xy-2514R    CCR5/CD195細(xì)胞表面趨化因子受體5抗體
xy-2515R    CD2CD2抗體
xy-0274R    C PeptideC-肽抗體
xy-0062R    Calretinin鈣結(jié)合蛋白抗體
xy-0155R    CRPC-反應(yīng)蛋白抗體
xym-0391M    CRP(C11F2)C-反應(yīng)蛋白單克隆抗體
xy-0035M    CREB-1環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白抗體
xy-0246R    CRF促腎上腺皮質(zhì)激素釋放因子抗體
xy-0382R    CRF促腎上腺皮質(zhì)激素釋放因子抗體
xy-15210R    C5orf545號染色體開放閱讀框54抗體
xy-2474R    CD93CD93抗體
xy-2476R    CCL6嗜酸粒細(xì)胞趨化蛋白CCL6抗體
xy-15254R    C6orf816號染色體開放閱讀框81抗體
xy-2475R    CCL4巨噬細(xì)胞炎性蛋白1β抗體
xy-2643R    CD158NK細(xì)胞抑制性受體2DL4抗體
xy-2644R    CD158iNK細(xì)胞抑制性受體2DS4抗體
xy-2645R    CD158eNK細(xì)胞抑制性受體3DL1抗體
xy-15271R    C7orf467號染色體開放閱讀框46抗體
xy-5948R    CIP2A蛋白磷酸酶PP2A癌抑制蛋白抗體
xy-2664R    Mannose Receptor巨噬細(xì)胞甘露糖受體CD206抗體
xy-2666R    C-REL淋巴細(xì)胞衍生C-型凝集素抗體
xy-15212R    C5orf605號染色體開放閱讀框60抗體
xy-2782R    CD44v5CD44V5抗體
xy-15133R    C22orf2322號染色體開放閱讀框23抗體
xy-2190R    Cytokeratin 19細(xì)胞角蛋白19抗體
xy-15025R    C1orf1471號染色體開放閱讀框147抗體
xy-2443R    CYP21膽固醇21-羥化酶抗體