腦源性tau蛋白激酶抗體 返回列表頁(yè)

腦源性tau蛋白激酶抗體

英文名稱(chēng) TTBK1
中文名稱(chēng) 腦源性tau蛋白激酶抗體
別    名 BDTK; Brain derived tau kinase; Brain-derived tau kinase; KIAA1855; Tau tubulin kinase 1; Tau-tubulin kinase 1; TTBK1; TTBK1_HUMAN.
 
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  細(xì)胞骨架  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 143kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TTBK1/BDTK
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics. Two isoforms of TTBK1 are expressed due to alternative splicing events.

Function:
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.

Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Contains 1 protein kinase domain.xy-15267R    C7ORF437號(hào)染色體開(kāi)放閱讀框43抗體
xy-15269R    C7orf447號(hào)染色體開(kāi)放閱讀框44抗體
xy-15290R    C8orf408號(hào)染色體開(kāi)放閱讀框40抗體
xy-15288R    C8orf378號(hào)染色體開(kāi)放閱讀框37抗體
xy-15293R    C8orf458號(hào)染色體開(kāi)放閱讀框45抗體
xy-15303R    C8orf808號(hào)染色體開(kāi)放閱讀框80抗體
xy-15325R    C9orf39號(hào)染色體開(kāi)放閱讀框3抗體
xy-15294R    C8orf478號(hào)染色體開(kāi)放閱讀框47抗體
xy-15295R    C8orf488號(hào)染色體開(kāi)放閱讀框48抗體
xy-15297R    C8orf588號(hào)染色體開(kāi)放閱讀框58抗體
xy-15300R    C8orf748號(hào)染色體開(kāi)放閱讀框74抗體
xy-15301R    C8orf768號(hào)染色體開(kāi)放閱讀框76抗體
xy-15302R    C8orf778號(hào)染色體開(kāi)放閱讀框77抗體
xy-15255R    C6orf976號(hào)染色體開(kāi)放閱讀框97抗體
xy-15256R    C7 補(bǔ)體C7抗體
xy-15257R    C7orf107號(hào)染色體開(kāi)放閱讀框10抗體
xy-15270R    C7orf457號(hào)染色體開(kāi)放閱讀框45抗體
xy-15307R    Complement component C9b補(bǔ)體C9b抗體
xy-15308R    C9orf1039號(hào)染色體開(kāi)放閱讀框103抗體
xy-15311R    C9orf1319號(hào)染色體開(kāi)放閱讀框131抗體
xy-15312R    C9orf135 9號(hào)染色體開(kāi)放閱讀框135抗體
xy-15291R    C8orf428號(hào)染色體開(kāi)放閱讀框42抗體
xy-15292R    C8orf448號(hào)染色體開(kāi)放閱讀框44抗體
xy-15104R    C20orf2020號(hào)染色體開(kāi)放閱讀框20抗體
xy-15194R    C4orf464號(hào)染色體開(kāi)放閱讀框46抗體
xy-15195R    C4orf514號(hào)染色體開(kāi)放閱讀框51抗體
xy-13300R    GBE1分支酶GBE1抗體
xy-10252R    phospho-Cofilin (Ser24)磷酸化絲切蛋白抗體
xy-10288R    C5R1補(bǔ)體成分5受體1抗體
xy-7070R    CDC2L6細(xì)胞分裂周期2樣蛋白激酶6抗體
xy-15164R    C3IP1 補(bǔ)體C3IP1抗體
xy-3721R    Phospho-CHK2 (Thr68)磷酸化細(xì)胞周期檢測(cè)點(diǎn)激酶2抗體
xy-3999R    CDK11周期素依賴性激酶11抗體
xy-2361R    CDK10周期素依賴性激酶10
xy-15305R    C8orf868號(hào)染色體開(kāi)放閱讀框86抗體