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Toll樣受體7抗體

英文名稱 TLR7
中文名稱 Toll樣受體7抗體
別    名 TLR-7;PRO285; TLR 7; Tlr7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 121kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLR7
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Tissue Specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.xy-11081R    FAT3鈣粘蛋白15抗體
xy-11267R    TCP1 beta分子伴侶復(fù)合體TCP-1β抗體
xy-9597R    Cdc25C細(xì)胞分裂周期蛋白25C抗體
xy-11274R    Complement C4 / C4a過敏毒素C4/補(bǔ)體C4抗體
xy-11283R    Cardiac FABP脂肪酸結(jié)合蛋白3抗體
xy-9630R    C16orf4816號(hào)染色體開放閱讀框48抗體
xy-1292R    CYP19細(xì)胞色素P450 19抗體
xy-1297R    CD28CD28抗體
xy-15053R    C1orf195 1號(hào)染色體開放閱讀框195抗體
xy-2419R    KIR2DL1NK細(xì)胞抑制性受體2DL1抗體
xy-15182R    C3orf673號(hào)染色體開放閱讀框67抗體
xy-10031R    CSN3κ-酪蛋白抗體
xy-2466R    Siglec 7唾液酸結(jié)合性免疫球蛋白樣凝集素7抗體
xy-9895R    CappuccinoCappuccino蛋白抗體
xy-9896R    Cyclooxygenase 3前列腺素過氧化物合成酶3抗體
xy-9905R    CFHL1補(bǔ)體因子H相關(guān)蛋白1抗體
xy-9907R    CPN2羧肽酶CPN2抗體
xy-9921R    CAMK2D鈣/鈣調(diào)素依賴蛋白激酶2D(CaMKIIδ)
xy-0372R    NT5C2胞漿-5′-核苷酸酶-Ⅱ抗體
xy-1035R    CD86CD86抗體
xy-0542R    CDK1周期素依賴性激酶1抗體
xy-0757R    CDK2周期素依賴性激酶2抗體
xy-0633R    CDK4周期素依賴性激酶4抗體
xy-0559R    CDK5周期素依賴性激酶5抗體
xy-15055R    C1orf2001號(hào)染色體開放閱讀框200抗體
xy-15242R    c6orf2236號(hào)染色體開放閱讀框223抗體
xy-2222R    cellulase纖維素酶抗體
xy-8541R    CLEC 4EC型凝集素4家族E抗體
xy-0236R    ChRM2毒蕈堿型乙酰膽堿受體抗體
xy-0441R    ChRM2毒蕈堿型乙酰膽堿受體M2抗體
xy-0544R    CIDEB促進(jìn)凋亡基因抗體
xy-0670R    C-jun原癌基因蛋白/活化蛋白1抗體
xy-6796R    CIDEC細(xì)胞死亡活化蛋白抗體
xy-1028R    Cytokeratin 19細(xì)胞角蛋白19抗體
xy-1005R    CK2細(xì)胞角蛋白2抗體
xy-1006R    CK4細(xì)胞角蛋白4抗體
xy-3879R    Cytochrome b245 Light Chain細(xì)胞色素b245輕鏈抗體
xy-15205R    C5ORF445號(hào)染色體開放閱讀框44抗體