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轉(zhuǎn)導(dǎo)素β1X連鎖受體蛋白1抗體

英文名稱 TBLR1
中文名稱 轉(zhuǎn)導(dǎo)素β1X連鎖受體蛋白1抗體
別    名 C21; DC42; F box like/WD repeat containing protein TBL1XR1; IRA1; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit; TBL1 related protein 1; TBL1-related protein 1; TBL1XR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; TBL1R_HUMAN.
 
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBLR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Function:
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Subunit:
Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.xy-0035R    CREB-1環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白抗體
xy-12424R    CSNK1G1酪蛋白激酶1γ1抗體
xy-15130R    C21orf8821號(hào)染色體開放閱讀框88抗體
xy-15137R    C21orf5421號(hào)染色體開放閱讀框54抗體
xy-1391R    CHK2細(xì)胞周期檢測點(diǎn)激酶2抗體
xy-1388R    Cyclin T1周期素依賴性激酶9抗體
xy-1390R    Cdc6細(xì)胞分裂周期蛋白6抗體
xy-1392R    CDC34細(xì)胞周期調(diào)控因子34
xy-1396R    CEBP Beta轉(zhuǎn)錄調(diào)節(jié)因子C/EBP β抗體
xy-1397R    CBPCREB結(jié)合蛋白抗體
xy-1601R    CCL11嗜酸粒細(xì)胞趨化蛋白抗體
xy-1618R    CD146黑色素瘤細(xì)胞粘附分子CD146抗體
xy-3125R    phospho-Cyclin E (Thr77)磷酸化周期素E抗體
xy-10034R    Alpha s2 Caseinα-s2酪蛋白抗體
xy-1500R    Cathepsin B組織蛋白酶B抗體
xy-1502R    CXCL10CXCL10趨化因子10/干擾素誘導(dǎo)蛋白10抗體
xy-1503R    CXCL14CXC趨化因子14抗體
xy-0813R    Casein酪蛋白抗體
xy-15184R    C4 binding protein 補(bǔ)體4結(jié)合蛋白
xy-2421R    CD158eNK細(xì)胞抑制性受體3DL1抗體
xy-15310R    C9orf1169號(hào)染色體開放閱讀框116抗體
xy-3210R    phospho-c-Jun(Ser63)磷酸化原癌基因c-Jun抗體
xy-0036R    phospho-CREB-1(Ser133)磷酸化CREB-1抗體
xy-15063R    C1orf2291號(hào)染色體開放閱讀框229抗體
xy-2232R    Cecropin殺菌肽/天蠶抗菌肽抗體
xy-3642R    Cullin 4ACullin 4a蛋白抗體
xy-3646R    CK3細(xì)胞角蛋白3抗體
xy-15209R    C5orf525號(hào)染色體開放閱讀框52抗體
xy-10390R    CCDC85B卷曲螺旋結(jié)構(gòu)域蛋白85B抗體
xy-5025R    Claudin 14緊密連接蛋白14抗體
xym-2271M    CMV(1F11)人巨細(xì)胞病毒單克隆抗體
xy-0719R    CEA癌胚抗原抗體
xy-2209R    CXCR3細(xì)胞表面趨化因子受體3抗體
xy-15064R    C1orf331號(hào)染色體開放閱讀框33抗體
xy-3061R    Phospho-CEBP alpha (Thr222 + Thr226)磷酸化轉(zhuǎn)錄調(diào)節(jié)因子CEBP α 抗體
xy-3062R    Phospho-CEBP beta (Ser105)磷酸化轉(zhuǎn)錄調(diào)節(jié)因子CEBP β抗體
xy-3063R    Phospho-CEBP beta (Thr235)磷酸化轉(zhuǎn)錄調(diào)節(jié)因子CEBP β抗體
xy-3264R    Phospho-CD18 (Ser756 + Thr758 + Thr759)磷酸化整合素β2/Integrin β2抗體
xy-3065R    Phospho-CD19 (Tyr531)磷酸化CD19抗體
xy-2753R    CENPA著絲粒蛋白A
xy-3066R    Phospho-CENPA (Ser7)磷酸化著絲粒蛋白A
xy-3068R    Phospho-CRMP2 (Thr514)磷酸化二氫嘧啶酶樣2抗體
xy-1487R    CC16克拉拉細(xì)胞蛋白抗體
xy-1481R    CD22B淋巴細(xì)胞粘附分子CD22抗體
xy-1598R    Cathepsin G組織蛋白酶G抗體
xy-1479R    CD80刺激分子B7-1蛋白抗體