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微管相關(guān)同源蛋白TPX2抗體

英文名稱 TPX2
中文名稱 微管相關(guān)同源蛋白TPX2抗體
別    名 C20ORF1; C20orf2; Chromosome 20 Open Reading Frame 1; Differentially expressed in cancerous and non-cancerous lung cells 2; Differentially expressed in cancerous and noncancerous lung cells 2; Differentially expressed in lung cells 2; Differentially expressed in lung cells; DIL 2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA 519; HCA519; HCTP 4; HCTP4; Hepatocellular carcinoma associated antigen 519; Hepatocellular carcinoma-associated antigen 519; p100; Preferentially expressed in colorectal cancer; Protein FLS353; REPP 86; repp86; Restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; Targeting protein for XKLP2; TPX 2; TPX2; TPX2 microtubule associated homolog; TPX2 microtubule associated protein homolog; TPX2_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
TPX2 is essential for spindle pole and mitotic spindle formulation, playing a role in the S and G2 phases of mitosis. It is also critical for the function of protein kinase Aurora A. TPX2 autophosphorylates Aurora A, targeting it to the spindle apparatus and allowing it to function in eukaryotic meiotic and mitotic cell cycles. TPX2 has also been found to be highly expressed in cancer cells.

Function:
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.

Subunit:
Interacts with AURKA. 

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.

Tissue Specificity:
Expressed in lung carcinoma cell lines but not in normal lung tissues.xy-11547R    Dab1磷脂蛋白受體Dab1抗體
xy-11548R    Phospho-Dab1 (Tyr198) 磷酸化磷脂蛋白受體Dab1抗體
xy-11550R    DLX2同源轉(zhuǎn)錄因子DLX2抗體
xy-2983R    Desmocollin 2橋粒糖蛋白2/橋粒糖蛋白3抗體
xy-6307R    Desmocollin 1橋粒糖蛋白1抗體
xy-6630R    Destrin 19肌動(dòng)蛋白解聚因子19抗體
xy-6929R    DCTN1動(dòng)力蛋白激活蛋白1抗體
xy-6725R    Desmoglein 1橋粒芯糖蛋白1
xy-5801R    DLC1胞漿動(dòng)力蛋白輕鏈1抗體
xy-11827R    DRGX背根神經(jīng)節(jié)同源蛋白DRGX抗體
xy-5909R    DeltaDDeltaD抗體
xy-5938R    DAT1神經(jīng)細(xì)胞特異性轉(zhuǎn)錄因子DAT1抗體
xy-6234R    DOK3對接蛋白3抗體
xy-5931R    DCUN1D2DCN1樣蛋白2抗體
xy-4949R    DNAJB6熱休克蛋白J2抗體
xy-6259R    Dyrk1B雙特異性酪氨酸磷酸化調(diào)節(jié)激酶1B抗體
xy-12999R    DGKE二?；视图っ?抗體
xy-2102R    DNA PKcsDNA依賴蛋白激酶催化亞基抗體
xy-12369R    DUX4雙同源框蛋白4抗體
xy-12285R    DAZ1無精癥缺失基因1抗體
xy-5257R    Phospho-CHK2 (ser516)磷酸化細(xì)胞周期檢測點(diǎn)激酶2抗體
xy-4150R    Kv2.1鉀通道蛋白DRK1抗體
xy-6001R    DRG1GTP發(fā)育調(diào)控結(jié)合蛋白1抗體
xy-6003R    DAL1細(xì)胞骨架4.1蛋白家族DAL1抗體
xy-3785R    DRAK2DAP凋亡誘導(dǎo)蛋白激酶2抗體
xy-5999R    DAB2信號(hào)轉(zhuǎn)導(dǎo)功能磷蛋白DAB2抗體
xy-6000R    DACH1細(xì)胞命運(yùn)決定因子DACH1抗體
xy-5998R    DAB2IPDab2相互作用蛋白抗體
xy-5056R    DECR1線粒體2,4-雙烯酰輔酶A還原酶1抗體
xy-7746R    DCTN3動(dòng)力蛋白激活蛋白亞基3抗體