T淋巴細(xì)胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體 返回列表頁

T淋巴細(xì)胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體

英文名稱 TFEB
中文名稱 T淋巴細(xì)胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體
別    名 Alpha TFEB; AlphaTFEB; bHLHe35; T cell transcription factor EB; T-cell transcription factor EB; TCFEB; Transcription factor EB; TFEB_HUMAN.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TFEB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

Function:
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Subunit:
Homodimer and heterodimer; with TFE3 or MITF.xy-13158R    FHOD1肢體畸形相關(guān)蛋白FHOD1抗體
xy-13159R    phospho-FHOD1 (Thr1141)磷酸化肢體畸形相關(guān)蛋白FHOD1抗體
xy-13160R    Fibulin 2纖連蛋白2抗體
xy-13161R    Fibulin 7纖連蛋白7抗體
xy-13162R    Ficolin 2彈性蛋白結(jié)合蛋白Fcn2抗體
xy-13137R    FAN1范可尼綜合征相關(guān)蛋白FAN1抗體
xy-13138R    FANCA范可尼貧血組蛋白A抗體
xy-13239R    FZD3卷曲蛋白3抗體
xy-13240R    FZR1細(xì)胞分裂周期樣蛋白20抗體
xy-13154R    Ferredoxin Reductase鐵氧化還原蛋白還原酶抗體
xy-13155R    Phospho-FGFR1 (Tyr154)磷酸化堿性成纖維細(xì)胞生長因子受體1抗體
xy-13147R    FBP17甲精結(jié)合蛋白17抗體
xy-13148R    FAU泛素樣核糖體蛋白S30/MNSF-β抗體
xy-13149R    FBXO2F-box蛋白2抗體
xy-13150R    FBXO45F-box蛋白45抗體
xy-13153R    FDPS法尼基二磷酸合酶抗體
xy-13151R    FCGRTIgG-Fc片斷受體轉(zhuǎn)運蛋白α抗體
xy-13129R    FACL4?；o酶A合成酶4抗體
xy-13130R    Factor D補體因子D抗體
xy-13131R    Factor I light chain補體因子I輕鏈抗體
xy-13132R    FAHD1FAHD1蛋白抗體
xy-13133R    phospho-FAK(Ser910)磷酸化粘著斑激酶抗體
xy-13134R    Phospho-FAK(Tyr576)磷酸化粘著斑激酶抗體
xy-13135R    FAKD3下頜發(fā)育不良綜合征相關(guān)蛋白FAKD3抗體
xy-13136R    FAM134BFAM134B蛋白抗體
xy-13139R    phospho-FANCA (Ser1149)磷酸化范可尼貧血組蛋白A抗體
xy-13140R    FANCC范可尼綜合征相關(guān)蛋白FANCC抗體
xy-13234R    FXYD6FXYD離子轉(zhuǎn)運調(diào)節(jié)因子6抗體
xy-13236R    FYBFyn結(jié)合蛋白抗體
xy-13237R    FYCO1鋅指蛋白FYCO1抗體