髓系細(xì)胞觸發(fā)受體樣轉(zhuǎn)錄因子2抗體 返回列表頁(yè)

髓系細(xì)胞觸發(fā)受體樣轉(zhuǎn)錄因子2抗體

英文名稱(chēng) TREML2
中文名稱(chēng) 髓系細(xì)胞觸發(fā)受體樣轉(zhuǎn)錄因子2抗體
別    名 C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2; TREM like transcript 2; Trem like transcript 2 protein; Triggering receptor expressed on myeloid cells like 2; Triggering receptor expressed on myeloid cells like protein 2; TRML2_HUMAN.
 
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TREML2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
TREML2 is expressed throughout B cell development in addition to being expressed on macrophages and neutrophils and is the only TREM molecule to be found on lymphocytes. TREML2 is expressed on B lineage cells early in development, and the highest level of expression is detected on those mature peripheral B cell subpopulations that are involved in the initial humoral immune response against bacterial pathogens. TREML2 is unique in that it lacks either the conserved transmembrane lysine residue or ITAM/ITIMs within its own cytoplasmic domain. Thus, TREML2 does not exhibit any of the features associated with classical tyrosine-based signaling.
Monocytes in the bone marrow or peripheral blood do not express detectable levels of TREML2, but its expression is up-regulated in conjunction with differentiation into macrophages. TREML2 is present on neutrophils in the bone marrow as well as the periphery, and inflammatory stimuli result in a dramatic increase in the expression of TREML2 on these cells in vivo.
TREML2 is a single-pass type I membrane protein, and it contains 1 Ig-like V-type (immunoglobulin-like) domain. It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties. 


Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counterreceptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Subunit:
Interacts with CD276 and this interaction enhances T-cell activationxy-2585R    FOXF1叉頭蛋白F1抗體
xy-13173R    FIP1L1高嗜酸性粒細(xì)胞綜合癥相關(guān)蛋白FIP1L1抗體
xy-7127R    FOXD4叉頭蛋白D4
xy-13163R    phospho-Filamin A (Ser1458)磷酸化細(xì)絲蛋白A抗體
xy-13164R    phospho-Filamin A (Ser1083)磷酸化細(xì)絲蛋白A抗體
xy-10170R    FLT3LFMS樣酪氨酸激酶3配體抗體
xy-13166R    FbxL4F-box富含亮氨酸重復(fù)蛋白4抗體
xy-13167R    FCER1G免疫球蛋白E受體Fc ε RIγ抗體
xy-13168R    FCGBPFcγ免疫球蛋白IgG結(jié)合蛋白抗體
xy-13169R    FENS1磷酸肌醇結(jié)合蛋白1抗體
xy-13170R    phospho-FGFR3 (Tyr724)磷酸化成纖維細(xì)胞生長(zhǎng)因子受體3抗體
xy-13171R    FHAD1叉頭相關(guān)結(jié)構(gòu)域包含蛋白1抗體
xy-13172R    Filensin串珠狀纖維結(jié)構(gòu)蛋白1抗體
xy-12362R    Fibromodulin纖維調(diào)節(jié)蛋白抗體
xy-13141R    phospho-FANCD2(Ser1404)磷酸化FANCD2抗體
xy-13142R    FANCE范可尼貧血相關(guān)蛋白E抗體
xy-13143R    FANCM范可尼貧血相關(guān)蛋白M抗體
xy-13144R    FARP1軟骨細(xì)胞Ezrin樣蛋白抗體
xy-13145R    FARSLA/CML33慢性粒細(xì)胞白血病33抗體
xy-12344R    FLVCR白血病病毒C亞類(lèi)受體蛋白FLVCR抗體
xy-12361R    FLRT1富含亮氨酸跨膜纖連蛋白1抗體
xy-12561R    FLRT2富含亮氨酸跨膜纖連蛋白2抗體
xy-12363R    FLRT3富含亮氨酸跨膜纖連蛋白3抗體
xy-10361R    Bovine Fibrinogen牛纖維蛋白原抗體
xy-13772R    FAM172AFAM172A蛋白抗體
xy-3159R    Phospho-FAK (Tyr397)磷酸化粘著斑激酶抗體
xy-3160R    Phospho-FAK(Tyr861)磷酸化粘著斑激酶抗體
xy-3146R    Phospho-FHIT (Tyr114)磷酸化脆性組氨酸三聯(lián)體抗體
xy-3158R    Phospho-FRA1 (Ser265)磷酸化FRA-1蛋白抗體
xy-3135R    Phospho-FADD (Ser191)磷酸化Fas相關(guān)死亡結(jié)構(gòu)域蛋白抗體
xy-3136R    Phospho-FLG (Tyr766)磷酸化堿性成纖維細(xì)胞生長(zhǎng)因子受體1抗體
xy-3137R    Phospho-FOXO1 + FOXO3 + FOXO4 (phospho T24 + T32)磷酸化叉頭蛋白家族抗體
xy-3138R    Phospho-FoxO3a (Ser318 + Ser321)磷酸化叉頭蛋白3A抗體.