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轉(zhuǎn)錄中介因子Tif1α抗體

英文名稱 TRIM24
中文名稱 轉(zhuǎn)錄中介因子Tif1α抗體
別    名 TIF1A; TIF1 Alpha; E3 ubiquitin-protein ligase Trim24; hTIF1; PTC6; RING finger protein 82; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A_HUMAN; TIF1ALPHA; Transcription intermediary factor 1-alpha; Transcriptional intermediary factor 1 alpha; Transcriptional intermediary factor 1; TRIM24; Tripartite motif containing 24; Tripartite motif-containing protein 24.
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIF1 Alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
TIF1 alpha mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains (a RING, a B box type 1 and a B box type 2) and a coiled coil region. 

Function:
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). xy-13247R    G protein alpha 13G蛋白結(jié)合蛋白α13/Gα13抗體
xy-13248R    G protein alpha 16G蛋白結(jié)合蛋白α16/Gα16抗體
xy-13249R    G protein alpha inhibitor 1G蛋白α抑制劑抗體
xy-13250R    G Protein alpha x+zG蛋白受體α x+z抗體
xy-13251R    GALC/Galactosylceramidase半乳糖神經(jīng)酰胺酶抗體
xy-10373R    Phospho-Glycogen synthase 1(Ser640)磷酸化葡萄糖合成酶1抗體
xy-10377R    Galectin-3半乳糖凝集素3抗體
xy-13642R    GRB7生長(zhǎng)因子受體結(jié)合蛋白7抗體
xy-13377R    GLT1D1糖基轉(zhuǎn)移酶1結(jié)構(gòu)域1抗體
xy-15368R    GPCR LGR7G蛋白偶聯(lián)受體LGR7蛋白抗體
xy-15370R    GPCR MRGX2 G蛋白偶聯(lián)受體MRGX2蛋白抗體
xy-15371R    GPCR RDC1G蛋白偶聯(lián)受體RDC1蛋白抗體
xy-15373R    GPCR TAS1R1G蛋白偶聯(lián)受體TAS1R1蛋白抗體
xy-15374R    GPCR TGR7G蛋白偶聯(lián)受體TGR7蛋白抗體
xy-15381R    GPR157G蛋白偶聯(lián)受體GPR157蛋白抗體
xy-15387R    GPR176G蛋白偶聯(lián)受體GPR176蛋白抗體
xy-15354R    GPR10 G蛋白偶聯(lián)受體GPR10蛋白抗體
xy-15352R    GPCR C5L2 G蛋白偶聯(lián)受體C5L2蛋白抗體
xy-15353R    GPCR EX33 G蛋白偶聯(lián)受體EX33蛋白抗體
xy-15355R    GPR102 G蛋白偶聯(lián)受體GPR102蛋白抗體
xy-15390R    GPR37L1G蛋白偶聯(lián)受體GPR37樣蛋白1抗體
xy-15356R    GPR105 G蛋白偶聯(lián)受體GPR105蛋白抗體
xy-15358R    GPR12 G蛋白偶聯(lián)受體GPR12蛋白抗體
xy-15357R    GPR110 proteinG蛋白偶聯(lián)受體GPR110蛋白抗體
xy-15359R    GPR125 G蛋白偶聯(lián)受體GPR125蛋白抗體
xy-15372R    GPCR RTAG蛋白偶聯(lián)受體RTA蛋白抗體
xy-15380R    GPR155G蛋白偶聯(lián)受體GPR155蛋白抗體
xy-15360R    GPR30G蛋白偶聯(lián)受體GPR30蛋白抗體
xy-15365R    GPR86G蛋白偶聯(lián)受體GPR86蛋白抗體
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xy-6892R    GMCL1L生殖細(xì)胞樣蛋白1樣蛋白抗體
xy-3178R    phospho-GAB2 (Tyr452)磷酸化接頭蛋白Gab 2抗體
xy-3182R    phospho-GAB2 (Tyr643)磷酸化接頭蛋白Gab2抗體
xy-3594R    GRIM19干擾素/維甲酸誘導(dǎo)凋亡相關(guān)基因抗體
xy-3183R    phospho-GAB2 (Ser623)磷酸化接頭蛋白Gab 2抗體
xy-13274R    GALNT13多肽N-乙酰氨基半乳糖轉(zhuǎn)移酶13抗體
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xy-13265R    GALE半乳糖瓦爾登轉(zhuǎn)化酶抗體
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xy-13267R    GALK2半乳糖激酶2抗體
xy-13268R    GALM半乳糖脫氫酶抗體