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調(diào)節(jié)染色體組裝激酶1抗體

英文名稱 TLK1
中文名稱 調(diào)節(jié)染色體組裝激酶1抗體
別    名 PKU beta; serine threonine protein kinase; Serine/threonine protein kinase tousled like 1; TLK1; Tousled like kinase 1; TLK1_HUMAN; Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1; KIAA0137.

說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  染色質(zhì)和核信號(hào)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Function:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Subunit:
Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.xy-5356R    phospho-GABBR2 (Ser783)磷酸化G氨基丁酸B型受體2抗體
xy-5357R    phospho-GABBR2 (Ser892) 磷酸化G氨基丁酸B型受體2抗體
xy-5720R    GDF10生長(zhǎng)分化因子10抗體（TGF-β超家族10）
xy-15369R    GPCR LOC51210G蛋白偶聯(lián)受體LOC51210蛋白抗體
xy-5715R    GIG34細(xì)胞生長(zhǎng)抑制蛋白34
xy-6579R    Growth Hormone生長(zhǎng)激素抗體
xy-13460R    GMPPAGDP甘露糖焦磷酸化酶抗體
xy-6564R    GPR171G蛋白偶聯(lián)受體171抗體
xy-11847R    GPM6B神經(jīng)細(xì)胞膜糖蛋白M6b
xy-6247R    GUK1鳥苷酸激酶GMK抗體
xy-4691R    Galactocerebroside半乳糖腦苷脂酶抗體
xy-7540R    GRK5G蛋白偶聯(lián)受體激酶5抗體
xy-7502R    GTP binding protein REM1GTP結(jié)合蛋白R(shí)EM1抗體
xy-4692R    phospho-GSK3 Alpha(Ser21)磷酸化糖原合酶激酶-3α抗體
xy-11461R    GDF7生長(zhǎng)分化因子7抗體
xy-7057R    Glucokinase regulatory protein葡萄糖激酶調(diào)節(jié)蛋白抗體
xy-8402R    GCLCγ谷氨酰半胱氨酸合成酶抗體（γ-GCSc）
xy-8403R    GCOM1GCOM1蛋白抗體
xy-8405R    GFOD2葡萄糖果糖還原酶2抗體
xy-8406R    GFRAL膠質(zhì)細(xì)胞系源性神經(jīng)營(yíng)養(yǎng)因子受體α1樣蛋白抗體
xy-8407R    GHDCGHDC蛋白抗體
xy-8408R    GK5甘油激酶5抗體
xy-8409R    GLB1L3β半乳糖苷酶1樣蛋白3抗體
xy-8410R    GLCCI1糖皮質(zhì)激素誘導(dǎo)轉(zhuǎn)錄蛋白1抗體
xy-8411R    GLIPR2腦膠質(zhì)瘤發(fā)病相關(guān)蛋白2抗體
xy-11725R    GDAP1神經(jīng)節(jié)苷脂誘導(dǎo)分化相關(guān)蛋白1抗體
xy-12015R    GPR18G蛋白偶聯(lián)受體18抗體
xy-12016R    GPR119G蛋白偶聯(lián)受體119抗體
xy-12017R    GPR88G蛋白偶聯(lián)受體88抗體
xy-12021R    GPR125G蛋白偶聯(lián)受體125抗體
xy-12006R    GRIK2谷氨酸受體紅藻氨酸離子2/谷氨酸受體6抗體
xy-12007R    GRIK3谷氨酸受體紅藻氨酸離子3/谷氨酸受體7抗體
xy-12008R    GRIK2 + GRIK3谷氨酸受體紅藻氨酸離子2/3抗體
xy-12009R    GluA4離子型谷氨酸受體4抗體
xy-12010R    phospho-GluA4 (Ser862)磷酸化離子型谷氨酸受體4抗體
xy-12011R    GRM1代謝型谷氨酸受體1A抗體