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Toll樣受體5抗體

英文名稱 TLR5
中文名稱 Toll樣受體5抗體
別    名 toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  免疫學  信號轉(zhuǎn)導  細胞膜受體  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse TLR5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. 

Function:
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Subunit:
Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity).xy-11621R    Guanylin鳥苷酸環(huán)化酶激活蛋白1抗體
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xy-13482R    GOLGA6高爾基體膜相關(guān)蛋白6抗體
xy-8155R    GM130高爾基體自身蛋白GM130抗體
xy-8157R    GMRP1糖代謝相關(guān)蛋白1抗體
xy-12268R    GPR64G蛋白偶聯(lián)受體64抗體
xy-8035R    GABARAPL1γ氨基丁酸受體相關(guān)蛋白樣1抗體
xy-8039R    GGPS1法尼基二磷酸合酶1抗體
xy-8040R    GNL1鳥嘌呤核苷酸結(jié)合蛋白1抗體
xy-11016R    GFAP delta膠質(zhì)纖維酸性蛋白GFAPδ抗體
xy-4960R    Beta galactosidaseβ半乳糖苷酶抗體
xy-11025R    Gigaxonin巨軸索神經(jīng)病蛋白GAN抗體
xy-6962R    GNAO1G蛋白偶聯(lián)受體結(jié)合蛋白O亞基A2抗體
xy-13491R    GOLT1A高爾基體轉(zhuǎn)運蛋白1A抗體
xy-9881R    GFI1B自主生長因子1B抗體
xy-9882R    GLCNEGLCNE蛋白抗體
xy-0604R    galectin 9半乳糖凝集素9抗體
xy-8719R    LRP130富含亮氨酸蛋白LRP130抗體
xy-11266R    GBF1蛋白轉(zhuǎn)運抑制劑GBF1抗體
xy-4887R    GOLPH2高爾基體膜蛋白GP73抗體
xy-4855R    GLUT1葡萄糖轉(zhuǎn)運蛋白1抗體
xy-11288R    GBP2G蛋白結(jié)合蛋白2抗體
xy-11289R    GBP2G蛋白結(jié)合蛋白2抗體
xy-8580R    GRAMD3丙型肝炎病毒-NS3反轉(zhuǎn)錄激活蛋白2抗體
xy-11050R    GJC2間隙連接蛋白47抗體
xy-11032R    Gliomedin神經(jīng)膠質(zhì)蛋白(肝癌相關(guān)基因2)抗體
xy-9910R    GPLD1糖蛋白磷脂酶D抗體
xy-1117R    GPR49G蛋白偶聯(lián)受體49抗體
xy-9536R    GemininDNA復制抑制因子抗體
xy-9920R    G protein alpha Inhibitor 2G蛋白α抑制蛋白2抗體
xy-13245R    G gamma4G蛋白偶聯(lián)受體γ4抗體