凝血調(diào)節(jié)蛋白/血栓調(diào)節(jié)素抗體 返回列表頁

凝血調(diào)節(jié)蛋白/血栓調(diào)節(jié)素抗體

英文名稱 Thrombomodulin
中文名稱 凝血調(diào)節(jié)蛋白/血栓調(diào)節(jié)素抗體
別    名 Thrombomodulin; CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  轉(zhuǎn)運蛋白  糖蛋白  內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58/63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD141 N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. 
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximay 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Function:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Subcellular Location:
Membrane; Single-pass type I membrane protein.xy-15450R    HELZ人腫瘤抑制蛋白抗體
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xy-15454R    HENMT1HEN1甲基轉(zhuǎn)移酶同源蛋白1抗體
xy-15488R    HIG2缺氧誘導基因2蛋白抗體
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xy-15456R    Hepatitis C Virus genotype 1a NS5 丙型肝炎病毒1a基因型NS5蛋白抗體
xy-15457R    HEV Capsid protein戊型肝炎病毒抗體
xy-15418R    HBP1HMG盒區(qū)內(nèi)含蛋白1抗體
xy-15419R    HBQ1血紅蛋白theta亞型1抗體
xy-15420R    HBS1Lhbs1樣蛋白抗體
xy-15422R    HCAP G縮素復合物亞型蛋白3抗體
xy-15423R    HCC1RNA結(jié)合蛋白39抗體
xy-15424R    HCCS全細胞色素C合成酶抗體
xy-15428R    HCP1血紅素轉(zhuǎn)運蛋白1抗體
xy-15429R    HCP5血紅素轉(zhuǎn)運蛋白5抗體
xy-15430R    HCST造血細胞信號轉(zhuǎn)導蛋白抗體
xy-15433R    HDHD1A鹵酸脫鹵酶樣水解酶域內(nèi)含蛋白1A抗體
xy-15446R    HECTD1E3連接酶抑制素受體抗體
xy-15434R    HDPTPHis 結(jié)構(gòu)域內(nèi)含酪氨酸磷酸酶蛋白抗體
xy-15436R    HEAB多聚腺苷酸因子Clp1蛋白抗體
xy-15444R    heavy chain cardiac Myosin心肌肌球蛋白重鏈抗體
xy-15445R    HECT E3 ubiquitin ligaseHECT E3泛素鏈接酶抗體
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xy-15480R    Hho1HHO1蛋白抗體
xy-3221R    Phospho-HP1 gamma (Ser93)磷酸化染色質(zhì)相關(guān)蛋白1-γ抗體
xy-3223R    Phospho-HSL (Ser863)磷酸化荷爾蒙敏感脂肪酶抗體
xy-3171R    phospho-Histone H1.4(Thr18)磷酸化組蛋白H1.4抗體
xy-15404R    HAGH羥酰谷胱甘肽水解酶蛋白抗體
xy-10329R    phospho-HDAC5 (Ser498)磷酸化組蛋白去乙?；?抗體
xy-2271R    HCMV/Cytomegalovirus Glycoprotein B人巨細胞病毒抗體
xy-3211R    Phospho-HDAC4 (Ser632) + HDAC5 (Ser498) + HDAC7 (Ser486)磷酸化組蛋白去乙?；?/5/7抗體
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