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端粒酶相關(guān)蛋白1抗體

英文名稱(chēng) TEP1
中文名稱(chēng) 端粒酶相關(guān)蛋白1抗體
別    名 omerase Associated pratein-1; TEP1; TLP1; TP1 TP-1; omerase protein component 1; omerase protein 1; p240; p80 omerase homolog; TEP1_HUMAN; omerase associated protein 1; omerase protein component 1; TROVE domain family, member 1; TROVE1; VAULT2.
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 290kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TP-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
omerase is an RNA-dependent DNA polymerase that uses an RNA component to add omeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the omeric repeat, the omerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the omerase-associated protein 1 (TEP1). omerase activity is low in most somatic cells, causing the gradual shortening of omeres which can ultimay lead to omere fusion and cell death. High levels of omerase activity are widely seen in cancerous cells and while recent experiments have suggested that omerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Function:
Component of the omerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).

Subunit:
Component of the omerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, 0, NHP2, GAR1, TEP1, EST1A, POT1 and a omerase RNA template component (TERC).xy-0344R    H5N1 Matrix Protein 2A型禽流感病毒H5N1-M2蛋白抗體
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