線粒體DNA拓普西異構(gòu)酶Ⅰ抗體 返回列表頁

線粒體DNA拓普西異構(gòu)酶Ⅰ抗體

英文名稱 *MT
中文名稱 線粒體DNA拓普西異構(gòu)酶Ⅰ抗體
別    名 Topoisomerase (DNA) I, mitochondrial; mitochondrial DNA topoisomerase I; DNA topoisomerase I, mitochondrial; *mt; 2900052H09Rik; *MT; *M_HUMAN; DNA topoisomerase I, mitochondrial; mitochondrial; *mt; Topoisomerase I mitochondrial.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human *mt
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Function:
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

Subcellular Location:
Mitochondrion.

Tissue Specificity:
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.xy-12385R    IPMK多磷酸肌醇激酶IPMK抗體
xy-13644R    IKAPIKK復合物相關(guān)蛋白抗體
xy-13645R    IQSEC2IQSEC2抗體
xy-13646R    Intersectin 2交叉蛋白2抗體
xy-13590R    Inosine triphosphate pyrophosphatase三磷酸肌苷焦磷酸酶抗體
xy-15493R    IDO吲哚胺2,3-雙加氧酶抗體
xy-10087R    IL-19白細胞介素19抗體
xy-7130R    Inhibin Alpha抑制素A/Inhibin α抗體
xy-7337R    Islet-1+2胰島素基因增強結(jié)合蛋白1/2抗體
xy-3192R    Phospho-IRAK1 (Ser376)磷酸化白介素-1受體相關(guān)激酶1抗體
xy-3193R    Phospho-IRAK1 (Thr209)磷酸化白介素-1受體相關(guān)激酶1抗體
xy-3194R    Phospho-IRAK1 (Thr387)磷酸化白介素-1受體相關(guān)激酶1抗體
xy-2993R    IRF3干擾素調(diào)節(jié)因子3
xy-3195R    Phospho-IRF3 (Ser396)磷酸化干擾素調(diào)節(jié)因子3
xy-2994R    IRF7干擾素調(diào)節(jié)因子7抗體
xy-3196R    Phospho-IRF7 (Ser471 + Ser472)磷酸化干擾素調(diào)節(jié)因子7抗體
xy-3198R    phospho-IRS1(Ser302)磷酸化胰島素受體底物-1抗體
xy-3199R    phospho-IRS1(Ser332 + Ser336)磷酸化胰島素受體底物-1抗體
xy-3200R    phospho-IRS1(Ser612)磷酸化胰島素受體底物-1抗體
xy-3203R    phospho-IRS1(Tyr1222)磷酸化胰島素受體底物-1抗體
xy-3204R    phospho-IRS1(Tyr895)磷酸化胰島素受體底物-1抗體
xy-3197R    phospho-IRS1(Ser1101)磷酸化胰島素受體底物-1抗體
xy-2628R    IL-28B/IL-28C白細胞介素28B抗體
xy-15544R    IER2即刻早期應(yīng)答基因2蛋白抗體
xy-8869R    IP3三磷酸肌醇抗體
xy-4040R    IL18BP白細胞介素18結(jié)合蛋白抗體
xy-3947R    IDH2草酰琥珀酸脫羧酶抗體
xy-15578R    IGLON5IgLON家族蛋白5抗體