DNA拓普西異構(gòu)酶Ⅱ抗體 返回列表頁

DNA拓普西異構(gòu)酶Ⅱ抗體

英文名稱 TOP2A
中文名稱 DNA拓普西異構(gòu)酶Ⅱ抗體
別    名 DNA topoisomeraseⅡalpha; TOPO II; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; TOP2; TP2A; TOP2A; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA Topoisomerase2; TOP 2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alpha 170kDa; Topoisomerase II alpha 170 kDa; TOP2A_HUMAN.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 174kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TOPO II alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-angiectasia. [provided by RefSeq].

Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.

Subunit:
Homodimer. Interacts with COPS5.

Subcellular Location:
Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.

Post-translational modifications:
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.xy-8172R    IKAROS鋅指蛋白IKAROS抗體
xy-9400R    Igj免疫球蛋白j鏈抗體
xy-4242R    IP3 receptor5-三磷酸肌醇受體1抗體
xy-4243R    ITPR25-三磷酸肌醇受體2抗體
xy-6229R    ID3DNA結(jié)合抑制因子3抗體
xy-4661R    CD275誘導(dǎo)協(xié)同刺激分子配體CD275抗體
xy-9202R    IGSF12免疫球蛋白超家族成員12抗體
xy-3946R    IDH3A草酰琥珀酸脫羧酶α抗體
xy-15520R    IFNA5干擾素alpha 5蛋白抗體
xy-4588R    IGF I胰島素樣生長因子1抗體
xy-4880R    IKK betaKB抑制蛋白激酶β抗體
xy-1236R    Involucrin囊包蛋白/內(nèi)披蛋白抗體
xy-7531R    Insulin Receptor R胰島素受體相關(guān)受體抗體
xy-7899R    INCA1INCA1蛋白抗體
xy-9018R    IQCEIQCE蛋白抗體
xy-10050M    IBDV雞傳染性法氏囊病病毒抗體
xy-4749R    Integrin beta 6整合素β6/Integrin β6抗體
xy-11256R    INPP5F磷酸肌醇磷酸酶蛋白INPP5抗體
xy-6841R    IL-4I1白細胞介素4誘導(dǎo)蛋白1抗體
xy-6840R    IEX1分化相關(guān)基因2蛋白/立即早期反應(yīng)蛋白抗體
xy-7637R    ICAM4細胞間粘附分子4抗體
xy-9633R    ITFG3整聯(lián)蛋白重復(fù)蛋白3抗體
xy-8683R    IGF2BP1胰島素樣生長因子ⅡmRNA結(jié)合蛋白1抗體
xy-8559R    IGF2BP2胰島素樣生長因子ⅡmRNA結(jié)合蛋白2抗體
xy-4847R    phospho-ITGB4(Tyr1530)磷酸化整合素β4抗體
xy-1822R    IGFBP1胰島素樣生長因子結(jié)合蛋白1抗體
xy-1823R    IGFBP4/IBP4胰島素樣生長因子結(jié)合蛋白4抗體
xy-1816R    ITGA7整合素α7抗體
xy-1811R    IL-7白介素7抗體
xy-1805R    IL-6R alpha白細胞介素6受體α/IL-6Rα抗體
xy-2428R    IL-9白介素9抗體
xy-1804R    Integrin alpha L整合素αL抗體Integrin αL
xy-1578R    Interferon alpha干擾素α抗體
xy-3402R    Phospho-INPPL1(Ser576)磷酸化肌醇聚磷酸鹽磷酸酶樣蛋白1抗體