腫瘤壞死因子受體相關(guān)因子2抗體 返回列表頁(yè)

腫瘤壞死因子受體相關(guān)因子2抗體

英文名稱 TRAF2
中文名稱 腫瘤壞死因子受體相關(guān)因子2抗體
別    名 E3 ubiquitin-protein ligase TRAF2; TNF-R2; TNF R2; MGC:45012; OTTHUMP00000022625; OTTHUMP00000064745; TNF receptor associated factor 2; TNF receptor-associated factor 2; TNF receptor-associated protein; TRAF 2; TRAF2; TRAF2_HUMAN; TRAP 3; TRAP; TRAP3; Tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3.
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  心血管  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  激酶和磷酸酶  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRAF2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The induction of the various cellular responses mediated by tumor necrosis factor is initiated by its interaction with the TNFR1 and TNFR2 cell surface receptors. TRAF2 interacts with the cytoplasmic domain of TNFR2. TRAF2 is a common signal transducer for TNFR2 and CD40 that mediates activation of NF kappa B.

Function:
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. xy-0474R    human Serum IgA人血清型免疫球蛋白A抗體
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xy-7866R    Intra Acrosomal Protein精子頂端體蛋白10抗體
xy-4964R    human secretory IgA人分泌型免疫球蛋白A
xy-11349R    ICA1胰島細(xì)胞自身抗原1抗體
xy-11321R    Islet 2胰島素基因增強(qiáng)結(jié)合蛋白2抗體
xy-0768R    IL-16白介素-16抗體
xy-1363R    AIF1離子鈣接頭蛋白抗體
xy-9464R    IRX4Iroquois同源蛋白4抗體
xy-6877R    IFRD1干擾素相關(guān)發(fā)育調(diào)節(jié)蛋白1抗體（神經(jīng)生長(zhǎng)因子誘導(dǎo)蛋白PC4）
xy-6870R    ILP2抑制細(xì)胞凋亡樣蛋白2抗體
xy-4750R    IFITM1干擾素誘導(dǎo)跨膜蛋白1抗體
xy-8690R    IFI44干擾素誘導(dǎo)蛋白44抗體
xy-6471R    ITPR35-三磷酸肌醇受體3抗體
xy-15525R    IFNW1干擾素omega 1蛋白抗體
xy-15521R    IFNA7干擾素alpha 7蛋白抗體
xy-0787R    IFN-Beta干擾素β抗體
xy-3529R    ID1DNA結(jié)合抑制因子1抗體
xy-8676R    IFI-202γ干擾素誘導(dǎo)蛋白202抗體
xy-0788R    intestinal FABP/IFABP/FABP2腸型脂肪酸結(jié)合蛋白抗體
xy-1291R    ING1生長(zhǎng)抑制因子基因1抗體
xy-0780R    IL-8/CXCL8白介素8抗體
xy-0317R    ILK-1整合素連接激酶-1抗體
xy-3235R    phospho-IKK alpha (Ser176 + Ser180)磷酸化KB抑制蛋白激酶α抗體
xy-3236R    Phospho-IKK alpha(Ser180) + IKK beta(Ser181)磷酸化KB抑制蛋白激酶α/β抗體
xy-3237R    Phospho-IKK alpha/beta (Ser176 + Ser180)磷酸化KB抑制蛋白激酶α/β抗體
xy-15563R    IFT46細(xì)胞纖毛內(nèi)轉(zhuǎn)運(yùn)同源蛋白46抗體
xy-2459R    IL-10RA白細(xì)胞介素-10受體a抗體
xy-2460R    IL-13Ra1白細(xì)胞介素-13受體a1抗體
xy-4015R    IRGM免疫相關(guān)鳥(niǎo)苷三磷酸酶基因抗體
xy-2461R    IL-13Ra2白細(xì)胞介素-13受體a2抗體
xy-2450R    I-309嗜酸粒細(xì)胞趨化蛋白CCL1抗體
xy-3226R    phospho-IGF1R (Tyr1161)磷酸化胰島素樣生長(zhǎng)因子1受體抗體