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端粒體復(fù)制結(jié)合因子1抗體

英文名稱 TRF1
中文名稱 端粒體復(fù)制結(jié)合因子1抗體
別    名 hTRF1 AS; NIMA interacting protein 2; NIMA-interacting protein 2; PIN 2; PIN2; t TRF1; omeric protein Pin2; omeric protein Pin2/TRF1; omeric repeat binding factor (NIMA interacting) 1; omeric repeat binding factor 1; omeric repeat binding protein 1; omeric repeat-binding factor 1; TERF 1; TERF1; TERF1_HUMAN; TRBF 1; TRBF1; TRF 1; TRF; TTAGGG repeat binding factor 1; TTAGGG repeat-binding factor 1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  免疫學(xué)  染色質(zhì)和核信號  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRBF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a omere specific protein which is a component of the omere nucleoprotein complex. This protein is present at omeres throughout the cell cycle and functions as an inhibitor of omerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq].

Function:
Binds the omeric double-stranded TTAGGG repeat and negatively regulates omere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (osome) that is involved in the regulation of omere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by omerase and protects chromosome ends; without its protective activity, omeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriay processed by DNA repair pathways.

Subunit:
Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (osome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation. Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interactions with GNL3L and TIN2 are mutually exclusive (By similarity).xy-0018R    IDE胰島素降解酶抗體
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