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促甲狀腺素受體抗體（C端）

英文名稱 TSHR (CT)
中文名稱 促甲狀腺素受體抗體（C端）
別    名 hTSHR I; hTSHRI; LGR 3; LGR3; MGC75129; Thyroid adenoma hyperfunctioning; Thyroid carcinoma with thyrotoxicosis; Thyroid Stimulating Hormone Receptor; Thyrotropin Receptor; Thyrotropin receptor I; TSH R; TSHR; Thyroid stimulating hormone receptor; TSHR_HUMAN.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  生長因子和激素  細(xì)胞膜受體  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat, Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TSHR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.

Function:
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).xy-0379R    IL-6白介素6抗體
xy-1032R    Inhibin Alpha抑制素A/Inhibin α抗體
xy-1674R    ILTV glycoprotein E雞傳染性喉氣管炎病毒糖蛋白E抗體
xy-0898R    intestinal FABP小腸型脂肪酸結(jié)合蛋白抗體
xy-1540R    IL-7Ra白細(xì)胞介素-7受體a抗體
xy-2093R    Integrin alpha 3整合素α3抗體
xy-2094R    Integrin beta 5整合素β5抗體
xy-2095R    Integrin alpha 1整合素α1抗體
xy-1959R    IL2 Receptor beta白介素2受體β鏈抗體 IL-2Rβ
xy-0536R    Interferon alpha 2b干擾素α2b抗體
xy-2471R    ICOS ligand誘導(dǎo)協(xié)同刺激分子配體CD275抗體
xy-10050R    IBDV雞傳染性法氏囊病病毒抗體
xy-2140R    IL-17白介素-17抗體
xy-5924R    IMPDH25'肌苷磷酸脫氫酶2抗體
xy-15545R    IER5L即刻早期應(yīng)答基因5樣蛋白抗體
xy-2250R    CD51整合素αV抗體
xy-2618R    IL-19/NG.1白細(xì)胞介素-19抗體
xy-2598R    IL-3白介素3抗體
xy-2600R    IL-3R alpha/CD123白介素3受體a鏈抗體
xy-2601R    IL5RA/CD125白介素-5受體α鏈抗體IL-5Rα
xy-2602R    IL-10RB/CRFB4白細(xì)胞介素-10受體β抗體
xy-2603R    IL-12RB1/CD212白細(xì)胞介素-12受體β1抗體
xy-2604R    IL12RB2白細(xì)胞介素-12受體β2抗體
xy-2605R    IL-15RA白介素15受體α抗體
xy-2606R    IL-17R/IL-17RA/CD217白介素17受體抗體
xy-2610R    IL-17RB白介素-17B受體抗體
xy-2616R    IL-18R Beta/IL1R7/CD218b白細(xì)胞介素-18受體β鏈抗體
xy-2621R    IL-21白介素21抗體
xy-2622R    IL-21R白介素21受體抗體
xy-2623R    IL-22白介素-22抗體
xy-2629R    IL-29/IFNL1白細(xì)胞介素29抗體
xy-2625R    IL-22BP/IL22RA2白介素22受體結(jié)合蛋白抗體
xy-2440R    IRAK4白介素-1受體相關(guān)激酶4抗體
xy-2500R    IRF4干擾素調(diào)節(jié)因子4抗體
xy-6457R    IGF-I Receptor beta胰島素樣生長因子1受體β/IGF-IRβ 抗體