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促甲狀腺素受體抗體（N端）

英文名稱 TSHR (NT)
中文名稱 促甲狀腺素受體抗體（N端）
別    名 hTSHR I; hTSHRI; LGR 3; LGR3; MGC75129; Thyroid adenoma hyperfunctioning; Thyroid carcinoma with thyrotoxicosis; Thyroid Stimulating Hormone Receptor; Thyrotropin Receptor; Thyrotropin receptor I; TSH R; TSHR; TSHR_HUMAN.
   
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TSHR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.xy-10492R    ING4ING4抗體
xy-10491R    rat IgA大鼠血清型IgA抗體
xy-2614R    MDA7/IL-24/IL-17F白介素-17F抗體
xy-15570R    IGFL1胰島素生長(zhǎng)因子樣家族成員1抗體
xy-2611R    IL-17C白介素-17C抗體
xy-2985R    ADM2中介素抗體
xy-10246R    IkB betaNF-kappa-B抑制子beta抗體
xy-13592R    IRF6干擾素調(diào)節(jié)因子6抗體
xy-7176R    IQGAP2
xy-15572R    IGFL4胰島素生長(zhǎng)因子樣家族成員4抗體
xy-10070R    IL-31白細(xì)胞介素31抗體
xy-10061R    IFI78干擾素誘導(dǎo)蛋白P78抗體
xy-10237R    Inhibin Alpha抑制素α/Inhibin α抗體
xy-4988R    IL-18白介素18抗體
xy-3621R    eIF4E真核翻譯起始因子4E抗體
xy-7712R    Importin4核蛋白4抗體（Ran結(jié)合蛋白4）
xy-4678R    IgHV免疫球蛋白重鏈可變區(qū)抗體
xy-5098R    IGFBP7胰島素樣生長(zhǎng)因子結(jié)合蛋白7抗體
xy-4064R    IGFBP6胰島素樣生長(zhǎng)因子結(jié)合蛋白6抗體
xy-4139R    IKB epsilonKB抑制蛋白激酶ε
xy-4115R    ITGB4整合素β4抗體
xy-5395R    phospho-IL-7Ra(Tyr449)磷酸化白細(xì)胞介素-7受體a抗體
xy-5396R    phospho-IRS1(Ser312)磷酸化胰島素受體底物-1抗體
xy-5397R    phospho-IRS-2(Ser731)磷酸化胰島素受體底物2抗體
xy-5398R    phospho-IKK beta(Ser471)磷酸化KB抑制蛋白激酶β抗體
xy-5399R    phospho-IKK beta(Ser740)磷酸化KB抑制蛋白激酶β抗體
xy-5440R    phospho-IKK beta(Ser733)磷酸化KB抑制蛋白激酶β抗體
xy-5441R    phospho-IKK beta(S474)磷酸化KB抑制蛋白激酶β抗體
xy-5442R    phospho-IKK beta(Ser476)磷酸化KB抑制蛋白激酶β抗體
xy-5443R    phospho-ILK-1(Thr173)磷酸化整合素連接激酶1抗體
xy-5444R    phospho-ILK-1(Ser246) 磷酸化整合素連接激酶1抗體
xy-5445R    phospho-ILK-1(Ser259)磷酸化整合素連接激酶1抗體
xy-5446R    phospho-IRS1(Thr176)磷酸化胰島素受體底物1抗體
xy-5450R    phospho-ICAM1(Tyr512)磷酸化細(xì)胞間粘附分子1抗體
xy-5452R    phospho-ITGB3(Tyr785)磷酸化整合素β3抗體
xy-5447R    phospho-IGF1R (Tyr980)磷酸化胰島素樣生長(zhǎng)因子1受體抗體
xy-5448R    phospho-IGF1R (Tyr1280)磷酸化胰島素樣生長(zhǎng)因子1受體抗體
xy-5449R    phospho-IGF1R (Tyr1165 + Tyr1166)磷酸化胰島素樣生長(zhǎng)因子1受體抗體


Function:
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).