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轉錄因子7類似物2抗體

英文名稱 TCF7L2
中文名稱 轉錄因子7類似物2抗體
別    名 E2 2; HMG box transcription factor 4; hTCF 4; Immunoglobulin transcription factor 2; ITF2; SEF2 1; SEF2 1A; SEF2 1B; SEF2; T cell factor 4; T cell specific HMG box; T cell specific transcription factor 4; TCF 4; TCF4; TCF7L2; TCF7L2 protein; hTCF-4; T-cell factor 4; T-cell-specific transcription factor 4; TCF-4; TF7L2_HUMAN; Transcription factor 7-like 2; Transcription factor 4; Transcription factor 7 like 2; Transcription factor 7 like 2 T cell specific HMG box.
  
說 明 書 0.1ml  0.2ml  
研究領域 心血管  染色質和核信號  轉錄調節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCF7L2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
TCF-4, transcription factor 4, is a basic helix-turn-helix transcription factor. This protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. The gene for TCF-4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting study indicates that it is required to maintain the crypt stem cells of the small intestine. TCF4 has many different splicing isoforms and they are expressed differentially in tissues and in cancers of different stages. Studies also indicate that variant of the TCF4 gene confers an increased risk of type 2 diabetes.

Function:
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.xy-1394R    Jab1Jun激活區(qū)域-連接蛋白1抗體
xy-3206R    phospho-JAK2(Tyr221)磷酸化蛋白酪氨酸激酶JAK-2抗體
xy-2808R    Jak3蛋白酪氨酸激酶JAK-3抗體
xy-3207R    Phospho-Jak3 (Tyr785)磷酸化蛋白酪氨酸激酶JAK-3抗體
xy-3208R    Phospho-Jak3 (Tyr980 + Tyr981)磷酸化蛋白酪氨酸激酶JAK-3抗體
xy-3209R    phospho-c-Jun(Thr93)磷酸化原癌基因c-Jun抗體
xy-0908R    JAK2蛋白質酪氨酸激酶JAK2抗體
xy-9706R    JWAJWA蛋白抗體
xy-11083R    Junctophilin 3連接蛋白JPH3抗體
xy-11086R    JAMC連接粘附分子C抗體
xy-1439R    JAK1蛋白質酪氨酸激酶JAK-1抗體
xy-8046R    JMJD2A組蛋白去甲基化酶JMJ2A抗體
xy-8047R    JMJD5組蛋白去甲基化酶JMJD5抗體
xy-5467R    phospho-JUP(Tyr550)磷酸化γ連環(huán)蛋白抗體
xy-12270R    JLPJNK相互作用蛋白4抗體
xy-10562R    JNK1+JNK2氨基末端激酶1/2抗體
xy-2592R    JNK1+JNK2+JNK3氨基末端激酶1/2/3抗體
xy-0501R    JNK1 + JNK3氨基末端激酶1/3抗體
xy-11084R    Junctophilin 4連接蛋白JPH4抗體
xy-9486R    JMJD7組蛋白去甲基轉移酶JMJD7抗體
xy-5463R    phospho-c-Jun(Tyr170)磷酸化原癌基因c-Jun抗體
xy-5466R    phospho-JunD(Ser255)磷酸化活化蛋白激酶D抗體
xy-5465R    phospho-JunB (Ser79)磷酸化活化蛋白激酶B抗體
xy-5464R    phospho-JunB(Ser259)磷酸化活化蛋白激酶B抗體
xy-12200R    phospho-JMJD2B(Thr305)磷酸化組蛋白去甲基化酶JMJD2B抗體
xy-13647R    JIP2絲裂原活化蛋白激酶相互作用蛋白2抗體
xy-13648R    JIP3絲裂原活化蛋白激酶相互作用蛋白3抗體
xy-1640R    phospho-JNK1 + 2 + 3 (Thr183+Tyr185)磷酸化氨基末端激酶1/2/3抗體
xy-3238R    Phospho-Jak1 (Tyr1022 + Tyr1023)磷酸化蛋白質酪氨酸激酶JAK-1抗體
xy-2900R    JNK2氨基末端激酶2抗體
xy-7614R    JMY連接介導調節(jié)蛋白抗體
xy-2997R    JNK3氨基末端激酶3抗體
xy-11228R    Phospho-JunB (Thr102 + Thr104)磷酸化活化蛋白激酶B抗體
xy-13601R    JHD1JmjC結構域組蛋白去甲基化酶H3-K36抗體