轉(zhuǎn)錄延伸因子Spt4抗體 返回列表頁

轉(zhuǎn)錄延伸因子Spt4抗體

英文名稱 SPT4
中文名稱 轉(zhuǎn)錄延伸因子Spt4抗體
別    名 Suppressor of Ty 4 homolog 1; DRB sensitivity-inducing factor 14 kDa subunit; DRB sensitivity-inducing factor small subunit; DSIF p14; DSIF small subunit; hSPT4; SPT4; SPT4H; SPT4H_HUMAN; SUPT4H `1; SUPT4H; Supt4h1; Transcription elongation factor spt4.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Rabbit, Zebrafish, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPT4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Function:
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Subcellular Location:
Nucleus.xy-2130R    Ki-67Ki67蛋白抗體
xy-2424R    KCNH1鉀離子通道蛋白EAG1抗體
xy-1395R    KLF6轉(zhuǎn)染抑癌基因KLF6抗體
xy-3649R    KLF8KLF樣轉(zhuǎn)錄因子8抗體
xy-3648R    KEAP1胞質(zhì)接頭蛋白Keap1抗體
xy-2303R    phospho-KLF5(Ser311)磷酸化腸道內(nèi)富含的Kruppel樣因子5抗體
xy-10495R    KMT6 (phospho Ser21)磷酸化抑癌蛋白EZH2抗體
xy-2231R    LYRICAEG-1抗體
xy-6309R    IL-6白介素6抗體
xy-2200R    LDL低密度脂蛋白抗體
xy-12310R    LRRC19LRRC19蛋白抗體
xym-4577M    LAMR1(M1S3)層粘連蛋白受體1單克隆抗體
xym-0940M    LAMR1(5D4)層粘連蛋白受體1單克隆抗體
xy-10126R    LATT細(xì)胞活化連接蛋白抗體
xy-2657R    LIX1LIX1抗體
xy-2044R    LOX 1凝集素樣氧化型低密度脂蛋白受體抗體
xy-2661R    MD1MD-1蛋白抗體
xy-2662R    MD-2MD-2蛋白抗體
xy-1311R    LYVE-1淋巴管內(nèi)皮透明質(zhì)酸受體抗體
xy-0897R    liver FABP肝臟型脂肪酸結(jié)合蛋白抗體
xy-8539R    Luciferase熒光素酶抗體
xy-7687R    LAP3亮氨酸氨基肽酶3抗體
xy-0824R    LFABP/FABP-1肝臟型脂肪酸結(jié)合蛋白抗體
xy-8527R    LPP2腫瘤抑制基因LPP2抗體
xy-2904R    LATS1腫瘤抑制基因LATS1抗體
xy-3247R    Phospho-LIMK1(Thr508) + LIMK2(Thr505)磷酸化單絲氨酸蛋白激酶1/2抗體
xy-3246R    Phospho-LATS1 (Ser909)磷酸化腫瘤抑制基因LATS1抗體
xy-3248R    phospho-LKB1(Ser334)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3249R    phospho-LKB1(Ser428)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3250R    Phospho-LKB1(Thr189)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-0456R    GNRH黃體激素釋放激素類似物抗體
xy-3254R    Phospho-Lamin A + C(Ser22)磷酸化核纖層蛋白A/C抗體
xy-3255R    Phospho-Lck (Tyr505)磷酸化淋巴細(xì)胞特異性蛋白酪氨酸激酶抗體
xy-2906R    Lyn膜相關(guān)蛋白酪氨酸激酶Lyn抗體