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基質(zhì)交感分子2抗體

英文名稱 STIM2
中文名稱 基質(zhì)交感分子2抗體
別    名 FLJ39527; KIAA1482; STIM 2; STIM2; STIM2_HUMAN; stromal interaction molecule 2.
 
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human STIM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

Function:
Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Subcellular Location:
Endoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.

Tissue Specificity:
Expressed in all tissues and tumor cell lines examined.xy-4051R    Nectin 4脊髓灰質(zhì)炎病毒受體相關(guān)蛋白4抗體
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xy-1550R    NCX1鈉鈣交換蛋白1抗體
xy-2057R    NCX3鈉鈣交換蛋白3抗體
xy-2030R    NMDAR1天冬氨酸受體抗體
xy-2013R    phospho-Nrf2 (Ser40)磷酸化核因子2相關(guān)因子2(Ser40)抗體
xy-10420R    Nemo-like kinaseNemo樣激酶抗體
xy-10421R    Phospho-Nemo-like kinase (Thr298)磷酸化Nemo樣激酶抗體
xy-10402R    phospho-NIFK (Thr238)磷酸化NIFK抗體
xy-10401R    phospho-NIFK (Thr230)磷酸化NIFK抗體
xy-13693R    NCKAP5NCKAP5蛋白抗體
xy-13694R    NOSTRIN一氧化氮合酶轉(zhuǎn)運(yùn)誘導(dǎo)抗體
xy-13656R    NSMAF中性鞘磷脂相關(guān)因子抗體
xy-15592R    NFIL3人白介素3介導(dǎo)核因子抗體
xy-13657R    NSP3SH2結(jié)構(gòu)域蛋白3A抗體
xy-2464R    Neuritin轉(zhuǎn)化神經(jīng)突起蛋白抗體
xy-13765R    NPIP-like protein 1NPIP樣蛋白1抗體
xy-6058R    Nicastrin老年性癡呆蛋白APH2抗體
xy-6060R    NARC1神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1抗體（前蛋白轉(zhuǎn)化酶枯草溶菌素9）
xy-12018R    NPFF1 ReceptorG蛋白偶聯(lián)受體147抗體
xy-3513R    Nur77孤兒核受體蛋白Nur77抗體
xy-3313R    Phospho-Nur77(Ser351)磷酸化孤兒核受體蛋白Nur77抗體
xy-0452R    NAIF1 protein核凋亡誘導(dǎo)因子蛋白1
xy-1067R    NMDAR2C谷氨酸受體2C抗體
xy-0175R    TrkB酪氨酸激酶B抗體
xy-1091R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9316R    NDE1核分布基因E同源蛋白1抗體
xy-9317R    NEK9絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9318R    phospho-NEK9(Thr210)磷酸化絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9319R    NNF1R多胺調(diào)控因子1抗體