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MEK1抑制蛋白1抗體

英文名稱 SMEK1
中文名稱 MEK1抑制蛋白1抗體
別    名 FLFL1; KIAA2010; MEK1 SUPPRESSOR 1; MSTP033; P4R3A_HUMAN; PP4R3 ALPHA; PP4R3A; PPP4R3A; PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA; Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1; SMEK homolog 1, suppressor of mek1 (Dictyosium); smek1; SMK1.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMEK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 Function:
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

Subunit:
Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.

Similarity:
Belongs to the SMEK family.
Contains 1 WH1 domain.

Database links:xy-5990R    ARMCX3ARM重復(fù)X連鎖蛋白ARMCX3抗體
xy-5988R    ARMCX1ARM重復(fù)X連鎖蛋白ARMCX1抗體
xy-5989R    ARMCX2ARM重復(fù)X連鎖蛋白ARMCX2抗體
xy-5991R    Apg10自噬相關(guān)蛋白10抗體
xy-6017R    ACBD6?；o酶A結(jié)合結(jié)構(gòu)域蛋白6抗體
xy-6019R    Aminoacylase 1氨基酰化酶1抗體
xy-3831R    Adipose Triglyceride Lipase脂肪甘油三酯脂酶抗體
xy-4002R    phospho-AMPK alpha-1 (Thr172)磷酸化腺苷單磷酸活化蛋白激酶α1抗體
xy-3847R    Amphiregulin雙調(diào)蛋白（結(jié)腸直腸細(xì)胞源性生長(zhǎng)因子）抗體
xy-5185R    phospho-AQP2(Ser264)磷酸化水通道蛋白2抗體
xy-5180R    AXL粘附相關(guān)激酶抗體
xy-5181R    phospho-AXL (Tyr698+Tyr702+Tyr703)磷酸化粘附相關(guān)激酶抗體
xy-5182R    phospho-AKT1 + AKT2 + AKT3 (Thr308+Thr309+Thr305)磷酸化蛋白激酶B抗體
xy-5187R    phospho-AQP2(Ser269)磷酸化水通道蛋白2抗體
xy-5186R    phospho-Amyloid Precursor Protein (Thr743)磷酸化APP淀粉樣肽前體蛋白抗體
xy-5188R    phospho-AKT1(Ser129)磷酸化蛋白激酶B抗體
xy-5189R    phospho-Amyloid Precursor Protein (Ser198)磷酸化APP淀粉樣肽前體蛋白抗體
xy-5190R    phospho-ATF4 (Ser245)磷酸化活化轉(zhuǎn)錄因子4抗體
xy-5191R    phospho-Androgen Receptor (Ser213)磷酸化雄激素受體抗體
xy-5192R    phospho-Androgen Receptor (Ser650)磷酸化雄激素受體抗體
xy-5193R    phospho-AKT1+2+3 (Tyr315+316+312) 磷酸化蛋白激酶AKT1,2,3抗體
xy-5194R    phospho-AKT1(Thr34)磷酸化蛋白激酶B抗體
xy-5195R    phospho-ATF2(Ser472)磷酸化活化復(fù)制因子2抗體
xy-9806R    APR3凋亡相關(guān)蛋白3抗體
xy-3871R    ATG18自噬相關(guān)蛋白18抗體
xy-3873R    ATG4A自噬相關(guān)蛋白4A抗體
xy-3876R    APOA4載脂蛋白A4抗體
xy-3874R    ALOX1212脂氧合酶抗體
xy-3877R    Angiotensin III血管緊張素III抗體
xy-4021R    ADCY3腺苷酸環(huán)化酶3抗體
xy-4171R    Angiomotin血管動(dòng)蛋白抗體
xy-6136R    Adenovirus 5 E1A腺病毒早期E1A蛋白抗體
xy-5170R    phospho-ATF2 (Ser44)磷酸化活化復(fù)制因子2抗體
xy-5171R    phospho-ATF2 (Ser94)磷酸化活化復(fù)制因子2抗體
xy-5213R    phospho-ATXN1(Thr236)磷酸化失調(diào)癥蛋白1抗體