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平滑肌樣蛋白1抗體

英文名稱 SMTNL1
中文名稱 平滑肌樣蛋白1抗體
別    名 Calponin homology associated smooth muscle protein; CHASM; OTTHUMP00000235021; Smoothelin like 1; Smoothelin like protein 1; SMTNL1.

說 明 書 0.2ml  
研究領域 細胞生物  信號轉導  轉錄調節(jié)因子  細胞骨架  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMTNL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
產品介紹 background:
SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010]

Function:
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).

Subcellular Location:
Cytoplasm ?myofibril. Cytoplasm ?myofibril ?sarcomere ?I band By similarity. Cytoplasm ?myofibril ?sarcomere ?M line. Nucleus. Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus,

Tissue Specificity:
Expressed in striated muscles, specifically in type 2a fibers (at protein level).

Post-translational modifications:
Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.xy-11397R    Arginase II精氨酸酶2抗體
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