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磷酸化鋅指轉(zhuǎn)錄因子SNAIL抗體

英文名稱 phospho-SNAIL (Ser246)
中文名稱 磷酸化鋅指轉(zhuǎn)錄因子SNAIL抗體
別    名 SNAIL (phospho S246); p-SNAIL (phospho S246); dJ710H13.1; Protein sna; Protein snail homolog 1; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI; snai1; SNAI1_HUMAN; Snail 1 homolog; Snail 1 zinc finger protein; SNAIL; Snail homolog 1 (Drosophila); SNAIL, Drosophila, homolog of, 1; SNAIL1.
  
說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
細胞定位 細胞核 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SNAIL around the phosphorylation site of Ser246
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

Function:
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Subcellular Location:
Nucleus. Cytoplasm. Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Tissue Specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.xy-12508R    ARF1ADP核糖基化因子1抗體
xy-12510R    ARA9乙型肝炎病毒X相關(guān)蛋白2抗體
xy-12511R    ARF5ADP核糖基化因子5抗體
xy-12512R    ARFBP1ADP核糖基化因子結(jié)合蛋白抗體
xy-12513R    ARFGAP3ADP核糖基化因子GTP酶激活蛋白1抗體
xy-12514R    ARFRP1ADP核糖基化因子相關(guān)蛋白1
xy-12515R    Argininosuccinate Lyase琥珀酸裂解酶抗體
xy-12516R    Arginyl tRNA synthetase精氨酰tRNA合成酶抗體
xy-12517R    Argonaute 3真核翻譯起始因子2C3抗體
xy-12518R    Argonaute 4真核翻譯起始因子2C4抗體
xy-12519R    ARHGAP15Rho GTP酶激活蛋白15抗體
xy-12520R    ARID1B抑癌基因結(jié)合蛋白ARID1B抗體
xy-12521R    ARIH2E3連接酶蛋白ARIH2抗體
xy-12522R    ARFL1ADP核糖基化樣因子1抗體
xy-12523R    ARL4ADP核糖基化因子樣蛋白4抗體
xy-12524R    ARP2肌動蛋白相關(guān)蛋白2/3抗體
xy-12527R    ARPC2肌動蛋白相關(guān)蛋白2/3亞型2抗體
xy-12528R    ARPC4肌動蛋白相關(guān)蛋白2/3亞型4抗體
xy-12530R    ARSI芳香基硫酸酯酶家族蛋白1抗體
xy-12531R    ART1腫瘤抑制相關(guān)蛋白PHEMX抗體
xy-12532R    ARVCF精神分裂癥與犰狳重復(fù)基因抗體
xy-10162R    ALDH1乙醛脫氫酶1型抗體
xy-12954R    phospho-Acetyl Coenzyme A Carboxylase alpha (Ser80)磷酸化乙酰輔酶A羧化酶抗體
xy-12955R    phospho-Acetyl Coenzyme A Carboxylase alpha (Ser1263)磷酸化乙酰輔酶A羧化酶抗體
xy-12956R    phospho-ABCA1 (Ser2054)磷酸化腺苷三磷酸結(jié)合盒轉(zhuǎn)運體A1抗體
xy-12957R    phospho-Aconitase 1 (Ser138)磷酸化鐵調(diào)節(jié)蛋白1抗體
xy-12958R    phospho-Aconitase 1 (Ser711)磷酸化鐵調(diào)節(jié)蛋白1抗體
xy-12952R    phospho-Acetyl Coenzyme A Carboxylase beta (Ser220)磷酸化乙酰輔酶A羧化酶抗體
xy-8997R    Annexin VI膜粘連蛋白6抗體
xy-9401R    ANKRD42錨蛋白重復(fù)結(jié)構(gòu)域蛋白42抗體
xy-7738R    Anillin胞環(huán)蛋白肌動蛋白結(jié)合蛋白抗體
xy-7697R    Adenovirus 5 E1A binding protein腺病毒5結(jié)合蛋白BS69抗體(骨形態(tài)發(fā)生蛋白受體相關(guān)分子1)
xy-2314R    APOA1載脂蛋白A1抗體