DNA交聯(lián)修復(fù)基因SNM1抗體 返回列表頁(yè)

DNA交聯(lián)修復(fù)基因SNM1抗體

英文名稱 SNM1
中文名稱 DNA交聯(lián)修復(fù)基因SNM1抗體
別    名 DCLRE1A; DNA cross link repair 1A; DNA cross link repair gene SNM1; PSO2.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 116kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SNM1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the
PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Function:
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.

Subunit:
Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1.

Subcellular Location:
Nuclear.

Tissue Specificity:
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.

DISEASE:
In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.

Similarity:
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.xy-9136R    ASB5含錨蛋白重復(fù)序列-細(xì)胞因子信號(hào)抑制物盒蛋白家族5抗體
xy-4733R    ABP1植物生長(zhǎng)激素ABP1抗體
xy-8450R    phospho-ATF2 (Thr55)磷酸化活化復(fù)制因子2抗體
xy-10465R    ADRA1Balpha 1腎上腺素能受體B抗體
xy-15533R    Bcl-2 alphaBcl2 alpha蛋白抗體
xy-9757R    BAT5白細(xì)胞抗原B相關(guān)轉(zhuǎn)錄蛋白5抗體
xy-9294R    BTBD1BTB/POZ結(jié)構(gòu)域蛋白1（丙型肝炎病毒的NS5A反轉(zhuǎn)錄蛋白8）抗體
xy-9298R    BCL7BBCL7B蛋白抗體
xy-9293R    BNC2堿性核蛋白2(鋅指蛋白basonuclin2)抗體
xy-9763R    BCL7CB細(xì)胞白血病/淋巴瘤蛋白7抗體
xy-6311R    BSCL2先天性脂肪代謝障礙蛋白2抗體（常染色體顯性遺傳痙攣性截癱17）
xy-7526R    BTG1B細(xì)胞遷移基因1抗體
xy-11710R    BEAN1脊髓小腦共濟(jì)失調(diào)蛋白BEAN1抗體
xy-12559R    B7-H6B7H6蛋白抗體
xy-1418R    BOb-1B細(xì)胞特異性轉(zhuǎn)錄因子抗體
xy-1485R    BIN1橋連整合因子蛋白抗體
xy-0612R    BADH2BADH2抗體(水稻)
xym-2011M    BCHE(1E8)丁酰膽堿酯酶單克隆抗體
xy-2063R    phospho-beta catenin (Tyr142)磷酸化β 連環(huán)素蛋白抗體
xy-2065R    Beta-lactoglobulinβ-乳球蛋白抗體
xy-2064R    Beta-lactoglobulinβ-乳球蛋白抗體
xy-2422R    BDKRB2緩激肽B2受體抗體
xy-0986R    Butyrylcholinesterase (NT)丁酰膽堿酯酶抗體(N端)
xy-0987R    BCHE (CT)丁酰膽堿酯酶抗體(C端)
xy-2473R    BLAMEBLAME抗體
xym-0910M    Batroxobin(5H4)巴曲霉毒素單克隆抗體
xy-0911R    Batroxobin蛇毒巴曲酶抗體
xy-0917R    BrdU溴脫氧尿苷抗體
xy-9114R    BAGE2腫瘤/睪丸抗原2.2抗體
xy-9115R    BAGE3腫瘤/睪丸抗原2.3抗體
xy-9116R    BAGE4腫瘤/睪丸抗原2.4抗體
xy-0044R    BNP腦鈉素/利鈉肽抗體
xy-1089R    B-RafB Raf抗體
xy-0802R    BRCA1乳腺癌易感基因1抗體
xy-1210R    FANCB乳腺癌易感基因2抗體