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SNRP70蛋白抗體

英文名稱(chēng) SNRP70
中文名稱(chēng) SNRP70蛋白抗體
別    名 RNPU1Z; Rnulp70; RPU1; Small nuclear ribonucleoprotein 70 (U1); Small nuclear ribonucleoprotein 70kD polypeptide (RNP antigen); Small nuclear ribonucleoprotein 70kDa (U1); Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen); snRNP70; Snrp 70; SNRP70; U1 70K; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U170K; U1AP; U1AP1; U1RNP.
    
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SNRP70
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.

Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

Subunit:
U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2.

Subcellular Location:
Nuclear.xy-5144R    proBNP腦納素前體抗體
xy-5145R    proBNP腦納素前體抗體
xy-6023R    BST1骨髓基質(zhì)干細(xì)胞抗原1抗體
xy-3055R    Phospho-Btk (Ser180)磷酸化蛋白酪氨酸激酶ATK抗體
xy-3069R    Phospho-BTK (Tyr223)磷酸化蛋白酪氨酸激酶ATK抗體
xy-3040R    Phospho-Bad (Ser112)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-3058R    phospho-Bim (Ser55)磷酸化細(xì)胞死亡調(diào)解子抗體
xy-3059R    phospho-Bim (Ser69)磷酸化細(xì)胞死亡調(diào)解子抗體
xy-5134R    BAG2Bcl-2結(jié)合抑凋亡蛋白2抗體
xym-0107M    beta-Amyloid (1-42)β淀粉樣肽1-42抗體
xy-12960R    phospho-beta Adducin (Ser713)磷酸化內(nèi)收蛋白抗體
xy-4941R    CD274程序性死亡配體1抗體
xy-10159R    B7-H1/PD-L1/CD274程序性死亡配體1抗體
xy-0107M    beta-Amyloid (1-42)β淀粉樣肽（1-42）抗體
xym-4713M    beta-Amyloid (1-42)β淀粉樣肽（1-42）單克隆抗體
xy-12440R    ABCB11膽汁酸鹽輸出泵/ATP結(jié)合盒轉(zhuǎn)運(yùn)蛋白11抗體
xy-12639R    BSPRYBSPRY蛋白抗體
xy-13684R    BAIAP2L2BAIAP2L2蛋白抗體
xy-3056R    Phospho-Bad (Ser136)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-3057R    Phospho-Bad (Ser155)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-0953R    hCG beta人β亞基人絨毛膜促性腺激素(β HCG)抗體
xy-0729R    BK channel鈣激活鉀通道蛋白 α 1抗體
xy-0868R    BK channel鈣激活鉀通道蛋白 α 1抗體
xy-0910R    Batroxobin Protein蛇毒巴曲酶抗體
xy-1153R    BidBH3結(jié)構(gòu)域凋亡誘導(dǎo)蛋白抗體
xy-0127R    BaxBax抗體
xy-0032R    Bcl-2Bcl-2抗體
xy-0248R    BDNF腦源神經(jīng)營(yíng)養(yǎng)因子抗體
xy-0217R    bFGF堿性成纖維細(xì)胞生長(zhǎng)因子抗體
xy-1015R    BRMS-1乳腺癌轉(zhuǎn)移抑制基因1抗體
xy-0292R    BSA牛血清白蛋白抗體
xy-0466R    Beta-caseinβ-酪蛋白抗體
xy-2455R    beta Glucan Receptorβ葡聚糖受體抗體