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當(dāng)前位置:上海信裕生物科技有限公司>>抗體>>一抗>> 磷酸化src原癌基因抗體
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品 牌Abcam
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更新時間:2015-06-11 10:06:05瀏覽次數(shù):293次
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英文名稱 phospho-Src (Ser75)
中文名稱 磷酸化src原癌基因抗體
別 名 Src (phospho S75); p-Src (phospho S75); ASV; Avian sarcoma virus; c SRC; CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA; cSrc; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; OTTHUMP00000174476; OTTHUMP00000174477; p60 Src; p60-Src; p60Src; pp60c src; pp60c-src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; Protooncogene SRC; Protooncogene SRC Rous sarcoma; Src; SRC Oncogene; SRC proto oncogene non receptor tyrosine kinase; SRC_HUMAN; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC 1; Tyrosine protein kinase SRC1; v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog; V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian); v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian.
說 明 書 0.1ml
產(chǎn)品類型 磷酸化抗體
研究領(lǐng)域 腫瘤 細胞生物 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 表觀遺傳學(xué)
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
細胞定位 細胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Src around the phosphorylation site of Ser75
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.xy-9679R C19orf2419號染色體開放閱讀框24抗體
xy-4851R Collagen alpha-1(II) chain Ⅱ型膠原α1蛋白/軟骨鈣素抗體
xy-11829R Cortexin 1皮質(zhì)素1抗體
xy-9666R C8orf708號染色體開放閱讀框70抗體
xy-6478R Carboxypeptidase H胰羧肽酶E抗體
xy-5405R phospho-CK18(Ser60)磷酸化細胞角蛋白18抗體
xy-9693R C20orf11220號染色體開放閱讀框112抗體
xy-9771R C10orf8810號染色體開放閱讀框88抗體
xy-9956R CRCT1富含半胱氨酸C端蛋白1抗體
xy-9957R CREG2E1A激活基因刺激蛋白2抗體
xy-9959R CWH43細胞壁合成蛋白43抗體
xy-9960R C19orf2919號染色體開放閱讀框29抗體
xy-5274R phospho-CDKN1A (Ser130)磷酸化p21蛋白抗體
xy-5275R Phospho-CHK2 (Thr387)磷酸化細胞周期檢測點激酶2抗體
xy-5276R phospho-CaMK2 alpha (Thr305)磷酸化鈣/鈣調(diào)素依賴蛋白激酶2α抗體
xy-5277R Phospho-CDK2 (Thr14)磷酸化周期素依賴性激酶2抗體
xy-5278R phospho-CHEK1 (Ser345)磷酸化細胞周期檢測點激酶1抗體
xy-5279R phospho-CDKN1B (Thr198)磷酸化P27抗體/周期素依賴激酶抑制劑抗體
xy-5280R phospho-CTNNA1 (Ser641)磷酸化α-連環(huán)蛋白抗體
xy-5281R Cyclin E2周期素E2抗體
xy-5282R phospho-CaMK2 beta gamma delta (Thr287)磷酸化鈣/鈣調(diào)素依賴蛋白激酶CAMK2B/D/G抗體
xy-4097R CASC3腫瘤易感候選基因3抗體
xy-5283R phospho-CASC3(Tyr181)磷酸化腫瘤易感候選基因3抗體
xy-5269R phospho-CREB-1(Ser142)磷酸化CREB-1抗體
xy-5270R phospho-CREB-1(Ser121)磷酸化CREB-1抗體
xy-5287R phospho-CDK6 (Tyr24)磷酸化周期素依賴性激酶6抗體
xy-5147R CBL2原癌基因CBL2抗體
xy-4071R phospho-CBL2 (Tyr674)磷酸化原癌基因CBL2抗體
xy-4095R CTNNBIP1β鏈接素相互作用蛋白1抗體
xy-5266R phospho-CTNNBIP1 (Thr43+Ser50)磷酸化β鏈接素相互作用蛋白1抗體
xy-4074R phospho-Beta catenin (Tyr86) 磷酸化β 連環(huán)素蛋白抗體
xy-4520R Chloroplast protease葉綠體蛋白酶抗體(植物)
xy-5267R phospho-CDC27 (Ser427)磷酸化后期促進復(fù)合蛋白3抗體
xy-5258R Phospho-Cofilin (Tyr140)磷酸化絲切蛋白抗體
xy-5259R phospho-CFL1 (Tyr89)磷酸化絲切蛋白抗體
xy-5260R Phospho-CHK2 (ser33)磷酸化細胞周期檢測點激酶2抗體
xy-5261R Phospho-cdc25A (Ser178)磷酸化細胞分裂周期蛋白25抗體
xy-5262R Phospho-cdc25A (Ser293)磷酸化細胞分裂周期蛋白25抗體
xy-4096R CDC27后期促進復(fù)合蛋白3抗體
xy-5264R phospho-CRK (Ser41)磷酸化CRK抗體
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