泛素樣蛋白特異性蛋白酶6抗體 返回列表頁(yè)

泛素樣蛋白特異性蛋白酶6抗體

英文名稱(chēng) SENP6
中文名稱(chēng) 泛素樣蛋白特異性蛋白酶6抗體
別    名 2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP 6; Senp6; SENP6_HUMAN; Sentrin specific protease 6; Sentrin-specific protease 6; Sentrin/SUMO specific protease SENP6; Sentrin/SUMO-specific protease SENP6; SSP 1; SSP1; SUMO 1 specific protease 1; SUMO 1 specific protease; SUMO-1-specific protease 1; SUMO1 specific protease 1; SUMO1 specific protease; SUMO1/sentrin specific peptidase 6; SUSP 1; SUSP1.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  表觀遺傳學(xué)  泛素  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 126kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SENP6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

Function:
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.

Subcellular Location:
Nucleus.xy-0841R    GLP-2胰高血糖素樣肽-2抗體
xy-1524R    GlyR alpha 1 + 2 + 3甘氨酸受體alpha 1/2/3型抗體
xy-1429R    GNAI3抑制型G蛋白α3抗體
xy-1464R    GnRHR促性腺激素釋放激素受體抗體
xy-1465R    GRB2生長(zhǎng)因子受體結(jié)合蛋白2抗體
xy-1452R    GATA3GATA結(jié)合蛋白3抗體
xy-1457R    GM-CSFR alpha粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體α抗體
xy-1475R    Gremlin骨形態(tài)形成蛋白拮抗蛋白抗體
xy-2768R    GCN2蛋白激酶GCN2蛋白抗體
xy-15363R    GPR78G蛋白偶聯(lián)受體GPR78蛋白抗體
xy-4214R    GIRK2G蛋白激活內(nèi)流鉀通道蛋白2抗體
xy-2769R    GRB10生長(zhǎng)因子受體結(jié)合蛋白10抗體
xy-3157R    Phospho-GRB10 (Tyr67)磷酸化生長(zhǎng)因子受體結(jié)合蛋白10抗體
xy-3148R    phospho-GSK-3 Beta(Thr390) 磷酸化糖原合酶激酶3β抗體
xy-3155R    Phospho-GCN2 (Thr899)磷酸化蛋白激酶GCN2蛋白抗體
xy-3156R    phospho-GCN2 (Thr667)磷酸化蛋白激酶GCN2蛋白抗體
xy-3165R    Phospho-Gab1 (Tyr627)磷酸化接頭蛋白Gab 1抗體
xy-3166R    Phospho-Gab1 (Tyr659)磷酸化接頭蛋白Gab 1抗體
xy-3190R    Phospho-Glycogen synthase 1(Ser641)磷酸化葡萄糖合成酶1抗體
xy-12334R    GCNT1GCNT1葡萄糖轉(zhuǎn)移酶抗體
xy-12304R    GIPC1胰島素樣生長(zhǎng)因子1受體相互作用蛋白1抗體
xy-13544R    Guanylyl Cyclase alpha 1鳥(niǎo)苷酸環(huán)化酶α1/GCS-α-1抗體
xy-13516R    GPR125G蛋白偶聯(lián)受體125抗體
xy-13507R    GPR84G蛋白偶聯(lián)受體84抗體
xy-13508R    GPCR G2AG蛋白偶聯(lián)受體G2A抗體
xy-13509R    GPR1G蛋白偶聯(lián)受體1抗體
xy-13510R    GPR100G蛋白偶聯(lián)受體100抗體
xy-13511R    GPR101G蛋白偶聯(lián)受體101抗體
xy-13512R    GPR103G蛋白偶聯(lián)受體103抗體
xy-13513R    GPR110G蛋白偶聯(lián)受體110抗體
xy-13514R    GPR12G蛋白偶聯(lián)受體12抗體