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鳥(niǎo)嘌呤核苷酸交換因子相關(guān)蛋白抗體

英文名稱 SERGEF
中文名稱 鳥(niǎo)嘌呤核苷酸交換因子相關(guān)蛋白抗體
別    名 Deafness locus associated putative guanine nucleotide exchange factor; DELGEF; Gef; Gnef; GNEFR; Guanine nucleotide exchange factor related protein; MGC128942; MGC141208; MGC141209; Secretion regulating guanine nucleotide exchange factor; TPH1.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Cat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SERGEF
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 Function:
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).

Subcellular Location:
Cytoplasmic and Nuclear

Tissue Specificity:
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

DISEASE:
A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Database links:

Entrez Gene: 26297 Humanxy-13480R    GOLGA3高爾基體膜相關(guān)蛋白抗體
xy-13481R    GOLGA5高爾基體膜相關(guān)蛋白5抗體
xy-13484R    GOLGA7高爾基體膜相關(guān)蛋白7抗體
xy-13485R    Golgi Complex高爾基復(fù)合體CFR1抗體
xy-13486R    Golgin 97高爾基體蛋白97抗體
xy-13487R    Golgin subfamily A member 4高爾基體蛋白A亞基4抗體
xy-13488R    GOLPH3高爾基體外周膜蛋白1抗體
xy-13490R    GOLPH4高爾基體膜蛋白抗體
xy-13492R    GORASP2高爾基體磷蛋白6抗體
xy-13493R    GOSR1高爾基SNAP受體復(fù)合物1抗體
xy-13494R    GOT1L1谷氨酸草酰乙酸轉(zhuǎn)氨酶1樣蛋白1抗體
xy-13539R    GPR52G蛋白偶聯(lián)受體52抗體
xy-13495R    GP210核膜糖蛋白210抗體
xy-8875R    GADD153GADD153抗體
xy-13540R    GPR57G蛋白偶聯(lián)受體57抗體
xy-12435R    FRAT2GSK-3結(jié)合蛋白FRAT2抗體
xy-10223R    phospho-gamma Adducin (Ser693)磷酸化內(nèi)收蛋白gamma抗體
xy-13284R    GAPT生長(zhǎng)因子受體結(jié)合適應(yīng)蛋白抗體
xy-13285R    GARNL3GARNL3蛋白抗體
xy-13286R    GARNL1Tuberin樣蛋白1抗體
xy-13287R    GARSX連鎖Charcot-Marie-Tooth神經(jīng)病變相關(guān)蛋白抗體
xy-13288R    GART甘氨酰胺核苷酸合成酶抗體
xy-13289R    GAS2生長(zhǎng)休止特定蛋白2抗體
xy-13467R    GNG11G蛋白γ11/Gγ11 抗體
xy-13358R    phospho-Girdin (Tyr1765)磷酸化肌動(dòng)蛋白結(jié)合蛋白Girdin抗體
xy-13351R    GGT7 heavy chainγ-谷氨酰轉(zhuǎn)肽酶7重鏈抗體
xy-13354R    GH2生長(zhǎng)激素2/胎盤(pán)特異性生長(zhǎng)激素抗體
xy-13356R    Giantin高爾基體相關(guān)蛋白GM130抗體
xy-13292R    GIPR胃泌素抑制肽受體抗體
xy-10078R    GM-CSFR alpha粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體α抗體
xy-2735R    GSTP1谷胱甘肽硫轉(zhuǎn)移酶pi基因抗體
xy-2885R    Gab2接頭蛋白Gab 2抗體
xy-4044R    Glucose 6 phosphatase alpha葡萄糖6磷酸酶α/G6Pase-α抗體