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SARA蛋白抗體

英文名稱 SARA
中文名稱 SARA蛋白抗體
別    名 CG15667; hSARA; LD33044p; Madh-interacting protein; MADHIP; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SAR1; SARA; SARA1; Smad anchor for receptor activation; SMADIP; ZFYV9_HUMAN; ZFYVE9; Zinc finger FYVE domain-containing protein 9.

說 明 書 0.2ml  
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo)  生長因子和激素  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 156kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SARA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Function:
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Subunit:
Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML. {ECO:0000269|PubMed:10615055,

Subcellular Location:
Cytoplasm. Early endosome membrane.xy-11016R    GFAP delta膠質(zhì)纖維酸性蛋白GFAPδ抗體
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xy-13491R    GOLT1A高爾基體轉(zhuǎn)運蛋白1A抗體
xy-9881R    GFI1B自主生長因子1B抗體
xy-9882R    GLCNEGLCNE蛋白抗體
xy-0604R    galectin 9半乳糖凝集素9抗體
xy-8719R    LRP130富含亮氨酸蛋白LRP130抗體
xy-11266R    GBF1蛋白轉(zhuǎn)運抑制劑GBF1抗體
xy-4887R    GOLPH2高爾基體膜蛋白GP73抗體
xy-4855R    GLUT1葡萄糖轉(zhuǎn)運蛋白1抗體
xy-11288R    GBP2G蛋白結(jié)合蛋白2抗體
xy-11289R    GBP2G蛋白結(jié)合蛋白2抗體
xy-8580R    GRAMD3丙型肝炎病毒-NS3反轉(zhuǎn)錄激活蛋白2抗體
xy-11050R    GJC2間隙連接蛋白47抗體
xy-11032R    Gliomedin神經(jīng)膠質(zhì)蛋白(肝癌相關(guān)基因2)抗體
xy-9910R    GPLD1糖蛋白磷脂酶D抗體
xy-1117R    GPR49G蛋白偶聯(lián)受體49抗體
xy-9536R    GemininDNA復(fù)制抑制因子抗體
xy-9920R    G protein alpha Inhibitor 2G蛋白α抑制蛋白2抗體
xy-13245R    G gamma4G蛋白偶聯(lián)受體γ4抗體
xy-1293R    GABA B Receptor 2G氨基丁酸B型受體2抗體
xy-1219R    GRP78葡萄糖調(diào)節(jié)蛋白78抗體（熱休克蛋白70蛋白5）
xy-0194R    GRP94葡萄糖調(diào)節(jié)蛋白94抗體
xy-0028M    GSK-3 Beta (CT)糖原合酶激酶-3β抗體
xy-0023M    GSK-3 beta (NT)糖原合酶激酶-3β抗體
xy-0136R    GTP cyclohydrolase 1三磷酸鳥苷環(huán)水解酶抗體
xy-1247R    mGluR5促代謝型谷氨酸受體5抗體
xy-0863R    GRO Alpha生長調(diào)節(jié)致癌基因-1抗體GROa
xy-1082R    GRK1G蛋白偶合受體激酶1抗體