鈉通道亞基β4抗體 返回列表頁

鈉通道亞基β4抗體

英文名稱 SCN4B
中文名稱 鈉通道亞基β4抗體
別    名 SCN4B_HUMAN. Sodium channel subunit beta-4.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN4B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation By similarity. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 

Function:
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.

Subunit:
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.xy-3491R    Phospho-HER3 (Tyr1289)磷酸化HER3受體抗體
xy-3073R    Phospho-HDAC4 (Ser246) + HDAC5 (Ser259) + HDAC7 (Ser155)磷酸化組蛋白去乙?；?/5/7抗體
xy-1421R    HP1 gamma異染色質(zhì)蛋白1-γ抗體
xy-1413R    Histone H1t組蛋白H1抗體
xy-1414R    HDAC1組蛋白去乙酰化酶1抗體
xy-15414R    HAUS3HAUS3蛋白抗體
xy-4517R    Hsp93熱休克蛋白93抗體
xy-3174R    Phospho-HDAC3 (Ser424)磷酸化組蛋白去乙?；?抗體
xy-3652R    Histone H2B組蛋白H2B抗體
xy-3653R    SCHAD短鏈L-3羥烷基輔酶A脫氫酶抗體
xy-2892R    HDAC9組蛋白去乙酰化酶9抗體
xy-2893R    HDAC10組蛋白去乙?；?0抗體
xy-3650R    HOXB4HOXB4抗體
xy-3214R    Phospho-HER2(Tyr1248)磷酸化HER2受體抗體
xy-2811R    HDAC6組蛋白去乙?；?抗體
xy-3215R    phospho-HDAC6 (Ser22)磷酸化組蛋白去乙?；?抗體
xy-2890R    HDAC7組蛋白去乙?；?抗體
xy-3216R    phospho-HDAC7 (Ser358)磷酸化組蛋白去乙?；?抗體
xy-2891R    HDAC8組蛋白去乙?；?抗體
xy-3184R    Phospho-HER4 (Tyr984)磷酸化HER4抗體
xy-6458R    HARS組氨酸t(yī)RNA連接酶抗體
xy-4529R    NDV HN protein雞新城疫血凝素－神經(jīng)氨酸酶抗體
xy-1387R    HSP105熱休克蛋白105抗體
xy-1405R    HNF1肝細(xì)胞核因子1α抗體
xy-1407R    HIF-1 beta缺氧誘導(dǎo)因子1β /HIF-1β抗體
xy-1409R    HSTF2熱休克轉(zhuǎn)錄因子2抗體
xy-0966R    HA tagHA tag標(biāo)簽抗體
xy-9066R    HIG1缺氧誘導(dǎo)基因1蛋白抗體
xym-2026M    HCG alpha(4A8)人絨毛膜促性腺激素α 亞基單抗
xym-2024M    HBsAg(H2F4)人乙型肝炎表面抗原單克隆抗體（檢測）
xym-2022M    HBeAg (2E9)人乙型肝炎e抗原單克隆（包被）抗體
xym-2023M    HBeAg(2E6)人乙型肝炎e抗原單克?。z測）抗體
xym-2118M    hHb(H5A3)小鼠抗人血紅蛋白單克隆抗體
xy-2001R    H1N1 Hemagglutinin 1甲型流感病毒血凝素抗體
xy-3213R    Phospho-HER2(Tyr1112)磷酸化HER2受體抗體
xy-2809R    HDAC4組蛋白去乙?；?抗體
xy-3212R    Phospho-HER2 (Tyr1221 + Tyr1222)磷酸化HER2受體抗體
xy-3127R    phospho-HDAC8 (Ser39)磷酸化組蛋白去乙?；?抗體