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SCRIBBLE蛋白抗體

英文名稱 SCRIBBLE
中文名稱 SCRIBBLE蛋白抗體
別    名 CRIB 1; CRIB1; hSCRIB; KIAA0147; LAP 4; LAP4; Mouse Circletail homolog; PDZ domain protein scribble; Protein LAP4; Protein scribble homolog; SCRB 1; SCRB1; SCRIB 1; Scrib; SCRIB_HUMAN; SCRIB1; Scribble; Scribble homolog 1; Scribble homolog 1 Drosophila; scribbled homolog (Drosophila); Vartul.
  
說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Macaque Monkey, Orangutan
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 175kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCRIBBLE
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Function:
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.xy-8042R    HIAT1海馬豐富基因轉(zhuǎn)錄蛋白1抗體
xy-8154R    Histone H2A.Z組蛋白H2AZ抗體
xy-15437R    HSF2 binding protein熱休克因子2結(jié)合蛋白抗體
xy-8041R    HEATR2HEATR2蛋白抗體
xy-15417R    HBLD2鐵硫簇整合同源物2蛋白抗體
xy-0887R    MV hemagglutinin glycoprotein麻疹病毒血凝素抗體
xy-11589R    HOXC5同源盒蛋白HOXC5抗體
xy-11567R    HES4轉(zhuǎn)錄因子HES4抗體
xy-11568R    HS1BP3造血干細胞特異性相關(guān)結(jié)合蛋白3抗體
xy-8316R    HDHD1HDHD1蛋白抗體
xy-8317R    HDHD2HDHD2蛋白抗體
xy-7803R    HCF-1宿主細胞因子1抗體
xy-7749R    HIST1H2AH組蛋白H2A/S抗體
xy-6664R    HRH2組胺受體H2抗體
xy-6665R    phospho-HRH1(Ser398)磷酸化組胺受體H1抗體
xy-6666R    HOXA11同源盒蛋白HOXA11抗體
xy-6663R    HRH1組胺受體H1抗體
xy-6667R    HOXA9同源盒蛋白HOXA9抗體
xy-6668R    HOXB5同源盒蛋白HOXB5抗體
xy-5840R    HEPACAM肝細胞粘附分子抗體
xy-10326R    Phospho-HDAC5 (Ser259)磷酸化組蛋白去乙酰化酶5抗體
xy-5388R    phospho-HDAC1 (Ser423+Ser421) 磷酸化組蛋白去乙?；?抗體
xy-5389R    phospho-HDAC2 (Ser394)磷酸化組蛋白去乙?；?抗體
xy-5392R    phospho-HOMER3 (Thr36)磷酸化HOMER3蛋白抗體
xy-6165R    HRAS+KRAS轉(zhuǎn)化蛋白p21抗體（原癌基因H-ras抗體）
xy-2972R    HES1轉(zhuǎn)錄因子HES-1抗體
xy-6191R    H3-K4-HMTase SETD7組蛋白H4-K4甲基轉(zhuǎn)移酶抗體
xy-5391R    HOMER3HOMER3蛋白抗體
xy-5340R    Phospho-HER3(Tyr1328)磷酸化HER3受體抗體
xy-5342R    Phospho-HER4 (Tyr1162)磷酸化HER4抗體
xy-5343R    Phospho-HER4 (Tyr1188)磷酸化HER4抗體
xy-3905R    HSD17B3羥類固醇脫氫酶17β3抗體