胃癌相關(guān)蛋白酪氨酸磷酸酶1抗體 返回列表頁

胃癌相關(guān)蛋白酪氨酸磷酸酶1抗體

英文名稱 SAP1
中文名稱 胃癌相關(guān)蛋白酪氨酸磷酸酶1抗體
別    名 BEM 2; BEM2; Brain-enriched membrane-associated protein tyrosine phosphatase 2; Phosphotyrosine phosphatase; Protein tyrosine phosphatase receptor type H; Protein tyrosine phosphatase receptor type H; PTPASE; PTPRH; PTPRH_HUMAN; R-PTP-H; Receptor-type tyrosine-protein phosphatase H; SAP-1; SAP1; Stomach cancer-associated protein tyrosine phosphatase 1; Transmembrane-type protein tyrosine phosphatase H; Transmembrane-type protein-tyrosine phosphatase type H.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞分化  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 122kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Function:
May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.

Subcellular Location:
Membrane. Cytoplasm.xy-12310R    LRRC19LRRC19蛋白抗體
xym-4577M    LAMR1(M1S3)層粘連蛋白受體1單克隆抗體
xym-0940M    LAMR1(5D4)層粘連蛋白受體1單克隆抗體
xy-10126R    LATT細(xì)胞活化連接蛋白抗體
xy-2657R    LIX1LIX1抗體
xy-2044R    LOX 1凝集素樣氧化型低密度脂蛋白受體抗體
xy-2661R    MD1MD-1蛋白抗體
xy-2662R    MD-2MD-2蛋白抗體
xy-1311R    LYVE-1淋巴管內(nèi)皮透明質(zhì)酸受體抗體
xy-0897R    liver FABP肝臟型脂肪酸結(jié)合蛋白抗體
xy-8539R    Luciferase熒光素酶抗體
xy-7687R    LAP3亮氨酸氨基肽酶3抗體
xy-0824R    LFABP/FABP-1肝臟型脂肪酸結(jié)合蛋白抗體
xy-8527R    LPP2腫瘤抑制基因LPP2抗體
xy-2904R    LATS1腫瘤抑制基因LATS1抗體
xy-3247R    Phospho-LIMK1(Thr508) + LIMK2(Thr505)磷酸化單絲氨酸蛋白激酶1/2抗體
xy-3246R    Phospho-LATS1 (Ser909)磷酸化腫瘤抑制基因LATS1抗體
xy-3248R    phospho-LKB1(Ser334)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3249R    phospho-LKB1(Ser428)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3250R    Phospho-LKB1(Thr189)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-0456R    GNRH黃體激素釋放激素類似物抗體
xy-3254R    Phospho-Lamin A + C(Ser22)磷酸化核纖層蛋白A/C抗體
xy-3255R    Phospho-Lck (Tyr505)磷酸化淋巴細(xì)胞特異性蛋白酪氨酸激酶抗體
xy-2906R    Lyn膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-3256R    Phospho-Lyn (Tyr507)磷酸化膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-3257R    Phospho-Lyn (Tyr397)磷酸化膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-1974R    LRRC4腦瘤相關(guān)基因抗體
xy-11091R    LSAMP大腦邊緣系統(tǒng)相關(guān)膜蛋白抗體
xy-11087R    LRFN2神經(jīng)突觸粘附樣分子1抗體
xy-11089R    LRFN4富含亮氨酸重復(fù)序列/Ⅲ型纖維連接蛋白4抗體
xy-11056R    Laminin alpha 4層粘蛋白α4抗體(Lamininα4)
xy-11055R    Laminin alpha 4層粘蛋白α4抗體(Lamininα4)
xy-11286R    lipocalin 1脂質(zhì)運(yùn)載蛋白1抗體
xy-11287R    Lymphotactin淋巴細(xì)胞趨化因子抗體
xy-11590R    LRP5L低密度脂蛋白受體5樣蛋白抗體