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組蛋白去乙?；笍?fù)合亞基SAP18抗體

英文名稱 SAP18
中文名稱 組蛋白去乙?；笍?fù)合亞基SAP18抗體
別    名 18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Histone deacetylase complex subunit SAP18; SAP18; SAP18_HUMAN; Sin3-associated polypeptide p18.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAP18
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 Function:
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.

Subunit:
Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. For the ASAP complex, the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Forms a complex with SIN3A and HDAC1. Interacts with SUFU.

Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the SAP18 family.xy-13613R    LRRC6富含亮氨酸重復(fù)蛋白6抗體
xy-6071R    LRP12低密度脂蛋白受體相關(guān)蛋白12抗體（抑制腫瘤蛋白7）
xy-6070R    phospho-LLGL1 + LLGL2(Ser650+Ser654)磷酸化相似腫瘤抑制基因HUGL抗體
xy-0705R    LDL receptor低密度脂蛋白受體抗體
xy-0108R    Leptin瘦素抗體
xy-5966R    LMO4乳腺腫瘤自身抗原LMO4抗體
xy-2649R    Lck/p56-LCK淋巴細(xì)胞特異性蛋白酪氨酸激酶抗體
xy-2658R    CD85c白細(xì)胞免疫球蛋白樣受體8抗體
xy-2654R    LTB4-R1/BLTR白三烯B4受體1抗體
xy-2656R    LIR-6白細(xì)胞免疫球蛋白樣受體6抗體
xy-2646R    LAG-3/CD223淋巴細(xì)胞活化基因-3抗體
xy-2647R    LAIR-1白細(xì)胞相關(guān)免疫球蛋白樣受體1抗體
xy-2650R    Langerin/CD207白細(xì)胞分化抗原CD207抗體
xy-2655R    LTB4-R2白三烯B4受體2抗體
xy-2648R    LAIR-2白細(xì)胞相關(guān)免疫球蛋白樣受體2抗體
xy-6069R    LLGL1相似腫瘤抑制基因HUGL抗體
xy-6319R    IL-1 Beta白介素1β抗體
xy-0814R    Beta-lactoglobulinβ-乳球蛋白抗體
xy-12150R    LPPR1脂質(zhì)磷酸磷酸酶相關(guān)蛋白1/可塑性相關(guān)基因3抗體
xy-12141R    LRFN1神經(jīng)突觸粘附樣分子1抗體
xy-9327R    LRCH1富含亮氨酸重復(fù)家庭蛋白1抗體
xy-9330R    LRCH4富含亮氨酸重復(fù)家庭蛋白4抗體
xy-0109R    Leptin receptor(long)瘦素受體抗體（長）
xy-1058R    LIF白血病抑制因子抗體
xy-1177R    Lingo-1Nogo受體反應(yīng)蛋白抗體
xy-0738R    Livin凋亡抑制蛋白抗體
xy-0821R    laminin層粘連蛋白抗體
xy-0759R    Lpin1 proteinLpin1 抗體
xy-0760R    Lpin1 proteinLpin1 抗體
xy-0816R    Lysozyme溶菌酶抗體
xy-0484R    Iumbrokinase蚓激酶抗體
xy-0409R    Leptin瘦素抗體