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SAPS結(jié)構(gòu)域家族1抗體

英文名稱 SAPS1
中文名稱 SAPS結(jié)構(gòu)域家族1抗體
別    名 PP6R1; Protein phosphatase 6, regulatory subunit 1; SAP190; SAPS domain family, member 1.

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAPS1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

Subunit:
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.

Subcellular Location:xy-12311R    LRRC23LRRC23蛋白抗體
xy-12312R    LRRC39LRRC39蛋白抗體
xy-8878R    LC3自噬微管相關(guān)蛋白輕鏈3抗體
xy-12342R    L3MBTL3L3MBTL3蛋白抗體
xy-12339R    LRRC25富含亮氨酸重復(fù)蛋白25抗體
xy-2631R    IL-31RA/CRL3白介素31受體a抗體
xy-9387R    LRSAM1LRSAM1蛋白抗體
xy-7336R    Limd1LIM結(jié)構(gòu)域蛋白1抗體
xy-2338R    Lactic acid bacterial protein surface乳酸菌菌體表面蛋白抗體
xy-4629R    Layilin透明質(zhì)酸受體抗體
xy-3908R    LTA4H白三烯A4水解酶抗體
xy-2342R    LXR alpha肝臟X受體抗體
xy-6542R    LAPTM4B溶酶體蛋白跨膜β4抗體
xy-6545R    LRRN5富含亮氨酸重復(fù)神經(jīng)元5抗體
xy-6546R    Lipophilin B親脂性蛋白B抗體
xy-6543R    LDOC1癌癥亮氨酸拉鏈下調(diào)因子1抗體
xy-6544R    LOXL2賴氨酰氧化酶相關(guān)蛋白2抗體
xy-5890R    Lumican基膜聚糖蛋白抗體
xy-10499R    Listeriolysin李斯特菌溶胞素抗體
xy-6249R    LCMT1亮氨酸羧基甲基轉(zhuǎn)移酶1抗體
xy-5937R    LETMD1宮頸癌原癌基因2抗體
xy-5790R    LOXL4賴氨酰氧化酶樣蛋白4抗體
xy-5810R    Lactoferrin乳鐵蛋白抗體
xy-7503R    Laminin 1+2層粘連蛋白1+2抗體
xy-6815R    LRRC15富含亮氨酸重復(fù)蛋白15抗體
xy-11530R    LAR受體蛋白酪氨酸磷酸酶F抗體
xy-13777R    Phospho-5-Lipoxygenase(Ser524)磷酸化5-脂氧合酶抗體
xy-2787R    LMP2低分子質(zhì)量蛋白2抗體
xy-2775R    LIMK1單絲氨酸蛋白激酶1抗體
xy-2796R    LMP7低分子量蛋白酶體7抗體
xy-0952R    LH促黃體生成素抗體
xy-4973R    Laminin alpha 1層粘蛋白α1抗體