絲裂原活化蛋白激酶底物1抗體 返回列表頁

絲裂原活化蛋白激酶底物1抗體

英文名稱 SAKS1/2B28
中文名稱 絲裂原活化蛋白激酶底物1抗體
別    名 LOC51035 2B28; 4930455J02Rik; D19Ertd721e; MGC124706; MGC6696; mY33K; UBXN1_HUMAN; Protein 2B28; RGD1309471; SAKS1; SAPK substrate protein 1; T25529; UBA/UBX 33.3 kDa protein; UBX domain containing protein 1; UBX domain protein 1; UBXD10; UBXN1.
   
說 明 書 0.2ml  
研究領域 細胞生物  信號轉導  激酶和磷酸酶  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAKS1/2B28
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
2B28 is a component of a complex composed of NGLY1, SAKS1, AMFR, VCP and RAD23B, where it acts as an adapter that directs VCP to polyubiquitinated proteins. 2B28 also interacts with Homer 2, which further suggests role for 2B28 in the regulation of protein degradation by ubiquitin-proteasome systems.

Function:
Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems. 2 named isoforms exist.

Subunit:
Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1.

Subcellular Location:
Cytoplasmxy-5781R    MIG7富含半胱氨酸蛋白質MIG7抗體
xy-5936R    MOS原癌基因絲氨酸/蘇氨酸蛋白激酶MOS抗體
xy-5792R    MCPIP1單核細胞趨化誘導蛋白1抗體
xy-5885R    Myosin heavy chain 1肌球蛋白重鏈抗體
xy-5876R    MMP-28基質金屬蛋白酶28抗體
xy-5875R    MMP-23基質金屬蛋白酶23抗體
xy-6551R    MimitinMYC誘導線粒體蛋白抗體
xy-5879R    MUC7粘蛋白7抗體
xy-5877R    MUC13粘蛋白13抗體
xy-5878R    MUC15粘蛋白15抗體
xy-5874R    MMP-22基質金屬蛋白酶22抗體
xy-6547R    MAG1肺癌轉移相關蛋白抗體
xy-6548R    MARVELD1候選腫瘤抑制基因MARVELD1抗體
xy-6550R    MTCP1成熟T淋巴細胞增殖蛋白1抗體
xy-6255R    MAPK8IP1絲裂原活化蛋白激酶8相互作用蛋白1抗體
xy-4129R    MYL6肌球蛋白輕鏈6抗體
xy-5479R    phospho-MEF2C(Ser59)磷酸化肌細胞增強因子2C抗體
xy-5472R    phospho-MCAM(Tyr641)磷酸化黑色素瘤細胞粘附分子CD146抗體
xy-4130R    MEF2C肌細胞增強因子2C抗體
xy-3910R    MSH γ1促黑細胞激素γ1抗體
xy-0102M    PKM2小鼠抗丙酮酸激酶-M2抗體
xy-3836R    PABP (Methyl Arg455/460)甲基化多聚腺苷酸結合蛋白抗體
xy-6004R    MIG6有絲分裂原誘導基因6抗體
xy-2988R    Mitofusin 2線粒體融合蛋白Mfn2抗體
xy-2931R    Mammaglobin A乳腺珠蛋白1抗體
xy-2380R    MYL9肌球蛋白輕鏈9抗體
xy-4060R    phospho-MYL9(Thr19)磷酸化肌球蛋白輕鏈9抗體
xy-3685R    MT-ND1NADH復合體1抗體
xy-1497R    MUC1乳腺癌相關抗原抗體
xy-4312R    MYST1組蛋白乙酰轉移酶MOF抗體
xy-2884R    Mesothelioma間質細胞蛋白抗體