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內(nèi)質(zhì)網(wǎng)脂質(zhì)轉(zhuǎn)運(yùn)相關(guān)蛋白2抗體

英文名稱(chēng) SPFH2
中文名稱(chēng) 內(nèi)質(zhì)網(wǎng)脂質(zhì)轉(zhuǎn)運(yùn)相關(guān)蛋白2抗體
別    名 C8orf2; Chromosome 8 open reading frame 2; Endoplasmic reticulum lipid raft associated protein 2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; ERLIN 2; Erlin-2; ERLIN2; ERLN2_HUMAN; HGNC:1356; MGC87072; NET32; SPFH 2; SPFH domain containing protein 2; SPFH domain family member 2; SPFH domain-containing protein 2; SPFH2; SPG18; Stomatin prohibitin flotillin HflC/K domain containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.

說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPFH2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SPFH2 is a ubiquitously expressed 339 amino acid protein that belongs to the band 7/mec-2 family. Localized to lipid raft-like domains in the membrane of the endoplasmic reticulum (ER), SPFH2 plays a crucial role in the ER-associated degradation (ERAD) pathway that removes metabolically regulated and aberrant proteins from the ER. Specifically, SPFH2 associates with IP3R-I (Inositol 1,4,5-triphosphate receptor I), a substrate of the ERAD pathway, and facilitates its polyubiquitination and subsequent degradation. Three isoforms of SPFH2 are expressed due to alternative splicing events.

Function:
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.

Subunit:xy-9867R    MYL7肌球蛋白輕鏈7抗體
xy-9868R    MYBPC3心臟肌球蛋白結(jié)合蛋白抗體
xy-9610R    MYH9肌球蛋白重鏈9抗體
xy-8562R    MLLT11髓系/淋巴或混合型白血病11抗體
xy-8461R    MX2干擾素誘導(dǎo)GTP結(jié)合蛋白MX2抗體
xy-6454R    BA46乳腺上皮細(xì)胞抗原BA46抗體
xy-0401R    Metal ion transporter擬南介金屬離子轉(zhuǎn)運(yùn)蛋白抗體
xy-0761R    Midnolin中腦核仁蛋白抗體
xy-9862R    MYH7B肌球蛋白重鏈7抗體
xy-9863R    MYOM1肌間蛋白1抗體
xy-9864R    MYOM2肌間蛋白2抗體
xy-9865R    MYLK3肌球蛋白輕鏈激酶3抗體
xy-9866R    MYLK2肌球蛋白輕鏈激酶2抗體
xy-6781R    MAP3K10絲裂原活化蛋白激酶3K10抗體
xy-6782R    MST4絲氨酸/蘇氨酸蛋白激酶MST4抗體
xy-7761R    Myosin VIIa肌球蛋白7a/常染色體隱性耳聾蛋白2抗體
xy-8084R    MBC1膀胱癌突變蛋白1抗體
xy-9376R    MURF3肌肉特定環(huán)指蛋白3抗體
xy-9377R    EDPF1腸細(xì)胞分化相關(guān)因子1抗體
xy-9379R    RNF62環(huán)指蛋白62抗體
xy-6933R    MICBMHC I類(lèi)鏈相關(guān)蛋白B
xy-7115R    MLC1膜蛋白MLC1抗體
xy-3278R    Phospho-MKP1 (Ser359)磷酸化絲裂原活化蛋白激酶磷酸酶-1抗體
xy-3279R    Phospho-MKP1 (Ser296)磷酸化絲裂原活化蛋白激酶磷酸酶-1抗體
xy-2992R    MLK3絲氨酸/蘇氨酸蛋白激酶MLK3抗體
xy-3280R    Phospho-MLK3(Thr277 + Ser281)磷酸化絲氨酸/蘇氨酸蛋白激酶MLK3抗體
xy-2995R    MSK1有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3281R    Phospho-MSK1 (Ser360)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3282R    Phospho-MSK1 (Ser212)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3283R    Phospho-MSK1 (Ser376)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3284R    Phospho-MSK1 (Thr581)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-2998R    MYPT1肌球蛋白磷酸酶抗體