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枯草桿菌蛋白酶同工酶1抗體

英文名稱 S1P/Subtilisin isozyme 1
中文名稱 枯草桿菌蛋白酶同工酶1抗體
別    名 kexin isozyme 1; KIAA0091; MBTP1_HUMAN； MBTPS1; membrane bound transcription factor peptidase, site 1; MGC138711; MGC138712; PCSK8; S1P; S1P endopeptidase; Site 1 protease; SKI 1; SKI1; Subtilisin isozyme 1; Subtilisin/kexin isozyme 1.

說 明 書 0.2ml  
研究領域 細胞生物  免疫學  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 96kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human S1P/Subtilisin isozyme 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

Function:
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Subunit:
Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.xy-5495R    phospho-MAP3K7IP1(Ser423)磷酸化轉(zhuǎn)化生長因子β活化激酶結(jié)合蛋白1抗體
xy-5496R    phospho-MAP3K7IP1(Thr431)磷酸化轉(zhuǎn)化生長因子β活化激酶結(jié)合蛋白1抗體
xy-5497R    phospho-MAPK3(Tyr204)磷酸化絲裂原活化蛋白激酶3抗體
xy-5498R    phospho-MEK2(Ser226)磷酸化絲裂原活化蛋白激酶激酶2抗體
xy-5501R    phospho-MEF2D(Ser180)磷酸化肌細胞特異性增強因子2D抗體
xy-5502R    phospho-MEF2D(Ser444)磷酸化肌細胞特異性增強因子2D抗體
xy-5503R    Phospho-MAPKAPK2(Ser272)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-5504R    phospho-MAPKAPK5(Thr182)磷酸化p38調(diào)節(jié)/激活蛋白激酶抗體
xy-5505R    phospho-MAPKAPK5(Ser93)磷酸化p38調(diào)節(jié)/激活蛋白激酶抗體
xy-5494R    phospho-MAP4K1(Ser171)磷酸化造血祖細胞激酶抗體
xy-4137R    PRAKp38調(diào)節(jié)/激活蛋白激酶抗體
xy-4136R    MEF2D肌細胞特異性增強因子2D抗體
xy-5493R    phospho-MAP4K4(Ser801)磷酸化絲裂原活化蛋白激酶MAP4K4抗體
xy-5500R    Phospho-MARCKS(Ser170)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-8304R    MTGR1髓易位基因相關蛋白1抗體
xy-7754R    BBS6巴德-畢德氏綜合征蛋白BBS6抗體
xy-7750R    MKLP2有絲分裂驅(qū)動蛋白樣2抗體
xy-7810R    MFAP1微原纖維膠原相關蛋白1抗體
xy-7799R    MND1減數(shù)分裂核分裂蛋白1抗體
xy-6386R    MDFIC肌原調(diào)節(jié)抑制蛋白抗體
xy-6388R    MDM2BP雙微體2癌基因結(jié)合蛋白抗體
xy-5788R    MMP20基質(zhì)金屬蛋白酶20
xy-5762R    MRP8多藥耐藥相關蛋白8抗體
xy-5761R    MRP7多藥耐藥相關蛋白7抗體
xy-5753R    phospho-MLF1 Interacting Protein(Thr78)磷酸化卡波西氏肉瘤皰疹病毒潛伏核抗原相互作用蛋白1抗體
xy-5751R    MATK酪氨酸蛋白激酶細胞分裂素抗體
xy-5752R    MLF1 Interacting Protein卡波西氏肉瘤皰疹病毒潛伏核抗原相互作用蛋白1抗體
xy-6231R    MAGEF1黑色素瘤抗原F蛋白家族1抗體
xy-5841R    MGAT5糖蛋白GNTVA抗體
xy-5842R    MIIPIGFBP2結(jié)合蛋白/遷移和侵潤抑制蛋白抗體
xy-11028R    MAP1B微管相關蛋白1B抗體
xy-4919R    MSH3錯配修復蛋白3抗體
xy-11092R    MDGA2神經(jīng)元膜糖蛋白錨定蛋白2抗體