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絲氨酸蛋白酶抑制劑SPINK5抗體

英文名稱 SPINK5/LEKTI
中文名稱 絲氨酸蛋白酶抑制劑SPINK5抗體
別    名 Hemofiltrate peptide HF7665; ISK5_HUMAN; LEKTI; Lympho-epithelial Kazal-type-related inhibitor; Lymphoepithelial Kazal type related inhibitor; NETS; NS; Serine peptidase inhibitor Kazal type 5; SPINK5; VAKTI.
  
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 118kDa
細(xì)胞定位 細(xì)胞外基質(zhì) 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPINK5/LEKTI
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.

Post-translational modifications:
Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.xy-8364R    phospho-NIPA(Ser354)磷酸化間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
xy-7764R    NUSAP1核仁和紡錘體相關(guān)蛋白1抗體
xy-2054R    Nkx2.5心臟特異性同源盒轉(zhuǎn)錄因子NKX2.5抗體
xy-2975R    Noggin指(趾)關(guān)節(jié)粘連NOG蛋白抗體
xy-0700R    NSBP1核小體結(jié)合蛋白1抗體
xy-11036R    Neurexin 1軸突蛋白1(Neurexin 1α)抗體
xy-11105R    Ninjurin 1神經(jīng)損傷誘導(dǎo)蛋白1抗體
xy-11106R    Ninjurin 2神經(jīng)損傷誘導(dǎo)蛋白2抗體
xy-6261R    NEK3絲氨酸/蘇氨酸蛋白激酶Nek3抗體
xy-5732R    NEK2中心體相關(guān)蛋白激酶Nek2抗體
xy-11435R    Neurogranin神經(jīng)顆粒素抗體
xy-11428R    Neuropeptide S神經(jīng)肽S抗體
xy-11429R    Neuropeptide S神經(jīng)肽S抗體
xy-11430R    NPSR1神經(jīng)肽S受體1/G蛋白偶聯(lián)受體154抗體
xy-11420R    NMUR1G蛋白偶聯(lián)受體66/神經(jīng)調(diào)節(jié)肽U受體1抗體
xy-11421R    NMUR2G蛋白偶聯(lián)受體FM4/神經(jīng)調(diào)節(jié)肽U受體2抗體
xy-11422R    Neuropeptide S神經(jīng)肽S抗體
xy-11409R    NR0B1腎上腺發(fā)育不全相關(guān)蛋白抗體
xy-7627R    NS5ATP9丙型肝炎病毒非結(jié)構(gòu)蛋白5A反式激活蛋白9抗體
xy-7074R    NoxaNoxa蛋白抗體
xy-7073R    NME5P53誘導(dǎo)細(xì)胞凋亡抑制蛋白抗體
xy-5526R    phospho-TrkB (Tyr705)磷酸化酪氨酸激酶B抗體
xy-5523R    phospho-NDEL1(Ser242)磷酸化中心粒蛋白Nudel抗體
xy-5524R    phospho-NDEL1(Thr219)磷酸化中心粒蛋白Nudel抗體
xy-3961R    NDUFS4線粒體復(fù)合物NDUFS4蛋白抗體
xy-3958R    NDUFA8NADH脫氫酶α家族8抗體
xy-3959R    NDUFV1NADH脫氫酶黃素蛋白1抗體
xy-3960R    NDUFV2NADH脫氫酶黃素蛋白2抗體
xy-3956R    NDUFA1NADH氧化還原酶輔酶1抗體
xy-8511R    NOD26膜內(nèi)在蛋白NOD26抗體
xy-8566R    Phospho-NMDAR2B (Tyr1474)磷酸化谷氨酸受體2B抗體
xy-8567R    Phospho-NMDAR2A + 2B (Tyr1246 + Tyr1252)磷酸化谷氨酸受體2A+2B抗體
xy-5271R    NEK6高度相似的細(xì)胞周期蛋白激酶NEK6抗體
xy-4839R    nonstructural protein 1A型流感病毒-NS1抗體（神經(jīng)氨酸酶1）
xy-10186R    NET1去甲腎上腺素轉(zhuǎn)運蛋白/神經(jīng)遞質(zhì)去甲腎上腺素轉(zhuǎn)運體抗體