SPOPL蛋白抗體 返回列表頁

SPOPL蛋白抗體

英文名稱 SPOPL
中文名稱 SPOPL蛋白抗體
別    名 HIB homolog 2; SPOPL_HUMAN; Roadkill homolog 2; Speckle type POZ protein like.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPOPL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SPOPL is a 392 amino acid nuclear protein that may be involved in ubiquitination and proteasomal degradation processes. Belonging to the Tdpoz family, SPOPL contains one BTB (POZ) domain and one MATH domain. SPOPL forms a complex with a member of the cullin family. The gene that encodes SPOPL includes 71,768 bases, four transcripts and maps to the human chromosome 2q22.1. Chromosomal arm 2q22-23 has been identified as one of fifteen hot spots thought to be involved in head and neck squamous cell carcinoma (HNSCC). Chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximay 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. 

Function:
SPOPL belongs to the Tdpoz family. It contains 1 BTB (POZ) domain and 1 MATH domain. In complex with a cullin SPOPL may act in ubiquitination and proteasomal degradation processes.

Subunit:
Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.

Subcellular Location:
Nuclearxy-10376R    Orexin A增食欲素A/欲激素A抗體
xy-15509R    Orexin A增食欲素A/欲激素A抗體
xy-7344R    OAS32'-5'-寡腺苷酸合成酶3抗體
xy-12377R    OSR2牙齒發(fā)育相關(guān)蛋白Osr2抗體
xy-3816R    Oct-4B(OCT4B-190)NT胚胎干細(xì)胞關(guān)鍵蛋白190抗體(N端)
xy-8998R    ORC1L起始識別復(fù)合蛋白亞基1抗體
xy-6236R    OTUB泛素特異性蛋白酶Otubain2抗體
xy-11469R    Oligophrenin 1精神發(fā)育遲滯相關(guān)蛋白Oligophrenin-1抗體
xy-8404R    OGFOD2末端多聚腺苷酸2蛋白抗體
xy-6559R    ORAV1口腔癌高表達(dá)的蛋白1抗體
xy-6560R    ORP4氧化固醇結(jié)合蛋白4抗體
xy-6558R    OLFM4抗細(xì)胞凋亡蛋白OLFM44抗體
xy-6556R    OCC1結(jié)腸癌過度表達(dá)蛋白1抗體
xy-6557R    OCIAD2卵巢癌免疫反應(yīng)抗原抗體
xy-5714R    OVCA1卵巢癌相關(guān)基因1抗體
xy-5723R    OSGIN1氧化應(yīng)激誘導(dǎo)生長抑制因子1抗體
xy-6334R    ORP8氧化固醇結(jié)合蛋白8抗體
xy-11229R    OTUB1泛素特異性蛋白酶OTB1抗體
xy-11764R    OPA1視神經(jīng)萎縮相關(guān)蛋白1抗體
xy-15593R    OAZ1鳥氨酸脫羧酶抗酶1抗體
xy-11626R    OR5T1嗅覺受體家族5亞基1抗體
xy-1111R    Oct-3/Oct-4胚胎干細(xì)胞關(guān)鍵蛋白抗體
xy-0974R    Oxytetracycline土霉素抗體
xy-9750R    ANKRD45腫瘤/睪丸抗原117
xy-15594R    OAZ2鳥氨酸脫羧酶抗酶2抗體
xy-15595R    OAZ3鳥氨酸脫羧酶抗酶3抗體
xy-11520R    Orexin Prepro食欲素前體蛋白OX抗體
xy-7025R    Otoraplin纖維細(xì)胞源性蛋白
xy-6724R    OTC鳥氨酸氨基甲酰轉(zhuǎn)移酶抗體
xy-5901R    OS9OS-9蛋白抗體
xy-4147R    Cenexin1精子尾部結(jié)構(gòu)蛋白抗體
xy-5530R    phospho-ODF2(Ser796)磷酸化精子尾部結(jié)構(gòu)蛋白抗體
xy-3687R    OGG18-羥基鳥嘌呤DNA糖基化酶
xy-11629R    OR10J3嗅覺受體家族10亞基J3抗體
xy-11624R    OR2A4嗅覺受體家族2亞基4抗體
xy-11628R    OR5P3嗅覺受體家族5亞基3抗體
xy-9369R    ODF3B外致密纖維蛋白3B抗體
xy-4917R    Osteocalcin骨鈣蛋白/骨鈣素抗體