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SPRED1蛋白抗體

英文名稱 SPRED1
中文名稱 SPRED1蛋白抗體
別    名 EVH1 domain-containing protein 1; EVH1/Sprouty domain containing protein; FLJ33903; hSpred 1; hSpred1; NFLS; SPRE1_HUMAN; SPRED 1; Spred-1; spred1; Sprouty related EVH1 domain containing 1; Sprouty related protein 1 with EVH 1 domain; Sprouty-related; Suppressor of Ras/MAPK activation.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPRED1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow.

Subcellular Location:
Cell membrane. Membrane > caveola. Nucleus. Localized in cholesterol-rich membrane raft/caveola fractions.

Tissue Specificity:
Weakly expressed in embryonic cell line (HEK-293).

Post-translational modifications:
Phosphorylated on tyrosine.xy-9061R    ODZ3固生蛋白3抗體
xy-9406R    CT135腫瘤/睪丸抗原135抗體
xy-9407R    OIF骨誘導(dǎo)因子抗體
xy-11203R    OCT6八聚體結(jié)合轉(zhuǎn)錄因子6抗體
xy-11194R    OLIG2少突膠質(zhì)細(xì)胞轉(zhuǎn)錄因子2抗體
xy-0807R    Os05g0477200 protein水稻白葉枯病菌Os05g0477200蛋白抗體
xy-8506R    OSTM1骨硬化病相關(guān)跨膜蛋白1抗體
xy-9915R    Orosomucoid 2類粘蛋白2抗體
xy-0830R    Oct4胚胎干細(xì)胞關(guān)鍵蛋白抗體
xy-0431R    OPG骨保護(hù)蛋白/護(hù)骨素抗體
xy-1077R    OCT2陽離子轉(zhuǎn)運(yùn)蛋白2抗體
xy-0019R    osteopontin骨橋蛋白/分泌型磷蛋白1抗體
xy-0026R    osteopontin骨橋蛋白抗體(分泌型磷蛋白1)
xy-1181R    Orexin-A增食欲素A/欲激素A
xy-1110R    Osterix成骨相關(guān)轉(zhuǎn)錄因子抗體
xy-0283R    Ovalbumin雞卵白蛋白/卵清蛋白抗體
xy-1095R    Orexin receptor 1+2丘腦分泌素受體1+2/食欲素受體1+2抗體
xy-1075R    OCT1陽離子轉(zhuǎn)運(yùn)器1抗體
xy-1698R    ox-LDL氧化低密度脂蛋白抗體
xy-0470R    Osteocalcin骨鈣蛋白/骨鈣素抗體
xy-13658R    Optineurin視神經(jīng)病變誘導(dǎo)蛋白抗體
xy-5017R    Oct2胚胎干細(xì)胞關(guān)鍵蛋白2抗體
xy-4052R    Oct-1胚胎干細(xì)胞關(guān)鍵蛋白1抗體
xy-5111R    OPRS1衰老相關(guān)Sigma受體蛋白抗體
xy-2128R    OST-beta有機(jī)溶質(zhì)轉(zhuǎn)運(yùn)蛋白OSTβ抗體
xy-2173R    Noelin嗅球蛋白1抗體
xy-11791R    OA1眼部白化病相關(guān)蛋白OA1/蛋白偶聯(lián)受體143抗體
xy-6295R    Oncostatin M癌基因蛋白抑瘤素M抗體