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Rho GTP酶激活蛋白13抗體

英文名稱 SRGAP1
中文名稱 Rho GTP酶激活蛋白13抗體
別    名 ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN.
Rho GTP酶激活蛋白13抗體
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 124kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRGAP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Rho GTP酶激活蛋白13抗體
PubMed PubMed
產(chǎn)品介紹 background:
SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimay leads to a decrease in actin polymerization.

Function:
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Subunit:
Homodimer (Probable). Forms heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG. 

Tissue Specificity:
Expressed in brain, lung, kidney, and testis.Rho GTP酶激活蛋白13抗體xy-10043R    PRRSV豬藍(lán)耳病病毒抗體
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xy-8279R    p400p400蛋白抗體
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xy-5776R    PDGF-D血小板源性生長(zhǎng)因子D(脊髓源性生長(zhǎng)因子B)
xy-2921R    PAR3非典型蛋白激酶C特定相互作用蛋白抗體
xy-5828R    PCDHB13原鈣粘蛋白13抗體
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xy-5843R    PCDHB11原鈣粘蛋白β11抗體
xy-6657R    PRX軸周蛋白PRX抗體
xy-4504R    PRRSV-GP5豬藍(lán)耳病病毒GP5蛋白抗體
xy-2277R    PAK1p21激活激酶1抗體
xy-4250R    PDIA2蛋白質(zhì)二硫鍵異構(gòu)酶抗體
xy-4251R    PHD1脯氨酰羥化酶抗體
xy-2311R    Classical swine fever virus抗豬瘟病毒抗體
xy-6611R    PLRP1胰脂肪酶相關(guān)蛋白1抗體
xy-5759R    PPP2R3蛋白質(zhì)磷酸酶2A亞基3抗體
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xy-7821R    PELOPELO蛋白抗體
xy-8306R    ProperdinP因子/備解素抗體
xy-7824R    PSF2PSF2蛋白抗體